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Prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients

Increasing evidence indicates that elevated neutrophil to lymphocyte ratio (NLR) are related with poor prognosis in various types of tumors. However, the prognostic role of NLR in patients with ovarian cancer (OC) remains controversial. Thus, the current meta-analysis aimed to investigate the progno...

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Autores principales: Zhou, Quan, Hong, Li, Zuo, Man-Zhen, He, Ze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620309/
https://www.ncbi.nlm.nih.gov/pubmed/28978169
http://dx.doi.org/10.18632/oncotarget.20196
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author Zhou, Quan
Hong, Li
Zuo, Man-Zhen
He, Ze
author_facet Zhou, Quan
Hong, Li
Zuo, Man-Zhen
He, Ze
author_sort Zhou, Quan
collection PubMed
description Increasing evidence indicates that elevated neutrophil to lymphocyte ratio (NLR) are related with poor prognosis in various types of tumors. However, the prognostic role of NLR in patients with ovarian cancer (OC) remains controversial. Thus, the current meta-analysis aimed to investigate the prognostic role of NLR in patients with OC. A total of 16 studies with 4,910 patients were included. By pooling hazard ratios (HRs) with 95% confidence intervals (CIs) and odds ratios (ORs) with 95% CIs from each study. The results demonstrated that elevated pretreatment NLR was significantly related to poor OS (HR: 1.50, 95% CI: 1.27-1.77) and PFS (HR: 1.53, 95% CI: 1.28-1.84) in patients with OC. Subgroup analyses was divided by ethnicity, sample size, histologic types, cut-off value of NLR, analysis method and NOS score, but the results did not showed any significant change the main results. This meta-analysis revealed that elevated pretreatment NLR might be a predicative factor of poor prognosis in OC patients.
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spelling pubmed-56203092017-10-03 Prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients Zhou, Quan Hong, Li Zuo, Man-Zhen He, Ze Oncotarget Meta-Analysis Increasing evidence indicates that elevated neutrophil to lymphocyte ratio (NLR) are related with poor prognosis in various types of tumors. However, the prognostic role of NLR in patients with ovarian cancer (OC) remains controversial. Thus, the current meta-analysis aimed to investigate the prognostic role of NLR in patients with OC. A total of 16 studies with 4,910 patients were included. By pooling hazard ratios (HRs) with 95% confidence intervals (CIs) and odds ratios (ORs) with 95% CIs from each study. The results demonstrated that elevated pretreatment NLR was significantly related to poor OS (HR: 1.50, 95% CI: 1.27-1.77) and PFS (HR: 1.53, 95% CI: 1.28-1.84) in patients with OC. Subgroup analyses was divided by ethnicity, sample size, histologic types, cut-off value of NLR, analysis method and NOS score, but the results did not showed any significant change the main results. This meta-analysis revealed that elevated pretreatment NLR might be a predicative factor of poor prognosis in OC patients. Impact Journals LLC 2017-08-10 /pmc/articles/PMC5620309/ /pubmed/28978169 http://dx.doi.org/10.18632/oncotarget.20196 Text en Copyright: © 2017 Zhou et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Meta-Analysis
Zhou, Quan
Hong, Li
Zuo, Man-Zhen
He, Ze
Prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients
title Prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients
title_full Prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients
title_fullStr Prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients
title_full_unstemmed Prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients
title_short Prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients
title_sort prognostic significance of neutrophil to lymphocyte ratio in ovarian cancer: evidence from 4,910 patients
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620309/
https://www.ncbi.nlm.nih.gov/pubmed/28978169
http://dx.doi.org/10.18632/oncotarget.20196
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