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Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer

BACKGROUND & AIMS: This study aims to analyze the feasibility and predictive value of thermal tomography (TT) for monitoring early treatment response in patients with locally advanced breast cancer (LABC) receiving neoadjuvant chemotherapy (NAC). METHODS: Patients with LABC who were due to recei...

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Autores principales: Wu, Qi, Li, Juanjuan, Sun, Si, Yao, Xiaoli, Zhu, Shan, Wu, Juan, Liu, Qian, Ding, Xiaojun, Shi, Manman, Li, Kaiyang, Sun, Shengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620312/
https://www.ncbi.nlm.nih.gov/pubmed/28978172
http://dx.doi.org/10.18632/oncotarget.16569
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author Wu, Qi
Li, Juanjuan
Sun, Si
Yao, Xiaoli
Zhu, Shan
Wu, Juan
Liu, Qian
Ding, Xiaojun
Shi, Manman
Li, Kaiyang
Sun, Shengrong
author_facet Wu, Qi
Li, Juanjuan
Sun, Si
Yao, Xiaoli
Zhu, Shan
Wu, Juan
Liu, Qian
Ding, Xiaojun
Shi, Manman
Li, Kaiyang
Sun, Shengrong
author_sort Wu, Qi
collection PubMed
description BACKGROUND & AIMS: This study aims to analyze the feasibility and predictive value of thermal tomography (TT) for monitoring early treatment response in patients with locally advanced breast cancer (LABC) receiving neoadjuvant chemotherapy (NAC). METHODS: Patients with LABC who were due to receive six cycles of NAC were examined by TT prior to NAC, the second cycle of NAC, the fourth cycle of NAC and surgery. Changes in TT parameters and ultrasonography were correlated with pathologic response to NAC, and the predictive value was assessed. RESULTS: Forty-four patients were evaluable for response (25 pathologic responders and 19 nonresponders). As early as after the first cycle of NAC, changes in the TT parameters ΔTs, ΔTn, and ΔTa correlated significantly with pathologic response (P < 0.05). The best predictor of pathologic response after the 6th cycle of NAC was TT (area under the receiver operating characteristic curve, 0.794), as opposed to cross-sectional areas and the longest diameter by ultrasonography. CONCLUSIONS: TT allows for monitoring early tumor response to NAC and can predict pathologic response in the early stages of therapy. Therefore, TT could be used as a novel imaging modality to monitor NAC treatment.
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spelling pubmed-56203122017-10-03 Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer Wu, Qi Li, Juanjuan Sun, Si Yao, Xiaoli Zhu, Shan Wu, Juan Liu, Qian Ding, Xiaojun Shi, Manman Li, Kaiyang Sun, Shengrong Oncotarget Clinical Research Paper BACKGROUND & AIMS: This study aims to analyze the feasibility and predictive value of thermal tomography (TT) for monitoring early treatment response in patients with locally advanced breast cancer (LABC) receiving neoadjuvant chemotherapy (NAC). METHODS: Patients with LABC who were due to receive six cycles of NAC were examined by TT prior to NAC, the second cycle of NAC, the fourth cycle of NAC and surgery. Changes in TT parameters and ultrasonography were correlated with pathologic response to NAC, and the predictive value was assessed. RESULTS: Forty-four patients were evaluable for response (25 pathologic responders and 19 nonresponders). As early as after the first cycle of NAC, changes in the TT parameters ΔTs, ΔTn, and ΔTa correlated significantly with pathologic response (P < 0.05). The best predictor of pathologic response after the 6th cycle of NAC was TT (area under the receiver operating characteristic curve, 0.794), as opposed to cross-sectional areas and the longest diameter by ultrasonography. CONCLUSIONS: TT allows for monitoring early tumor response to NAC and can predict pathologic response in the early stages of therapy. Therefore, TT could be used as a novel imaging modality to monitor NAC treatment. Impact Journals LLC 2017-03-25 /pmc/articles/PMC5620312/ /pubmed/28978172 http://dx.doi.org/10.18632/oncotarget.16569 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Clinical Research Paper
Wu, Qi
Li, Juanjuan
Sun, Si
Yao, Xiaoli
Zhu, Shan
Wu, Juan
Liu, Qian
Ding, Xiaojun
Shi, Manman
Li, Kaiyang
Sun, Shengrong
Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer
title Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer
title_full Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer
title_fullStr Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer
title_full_unstemmed Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer
title_short Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer
title_sort thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620312/
https://www.ncbi.nlm.nih.gov/pubmed/28978172
http://dx.doi.org/10.18632/oncotarget.16569
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