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A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast

In budding yeast, cell cycle progression and ribosome biogenesis are dependent on plasma membrane growth, which ensures that events of cell growth are coordinated with each other and with the cell cycle. However, the signals that link the cell cycle and ribosome biogenesis to membrane growth are poo...

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Autores principales: Clarke, Jesse, Dephoure, Noah, Horecka, Ira, Gygi, Steven, Kellogg, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620368/
https://www.ncbi.nlm.nih.gov/pubmed/28794263
http://dx.doi.org/10.1091/mbc.E17-01-0081
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author Clarke, Jesse
Dephoure, Noah
Horecka, Ira
Gygi, Steven
Kellogg, Douglas
author_facet Clarke, Jesse
Dephoure, Noah
Horecka, Ira
Gygi, Steven
Kellogg, Douglas
author_sort Clarke, Jesse
collection PubMed
description In budding yeast, cell cycle progression and ribosome biogenesis are dependent on plasma membrane growth, which ensures that events of cell growth are coordinated with each other and with the cell cycle. However, the signals that link the cell cycle and ribosome biogenesis to membrane growth are poorly understood. Here we used proteome-wide mass spectrometry to systematically discover signals associated with membrane growth. The results suggest that membrane trafficking events required for membrane growth generate sphingolipid-dependent signals. A conserved signaling network appears to play an essential role in signaling by responding to delivery of sphingolipids to the plasma membrane. In addition, sphingolipid-dependent signals control phosphorylation of protein kinase C (Pkc1), which plays an essential role in the pathways that link the cell cycle and ribosome biogenesis to membrane growth. Together these discoveries provide new clues as to how growth-­dependent signals control cell growth and the cell cycle.
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spelling pubmed-56203682017-12-16 A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast Clarke, Jesse Dephoure, Noah Horecka, Ira Gygi, Steven Kellogg, Douglas Mol Biol Cell Brief Reports In budding yeast, cell cycle progression and ribosome biogenesis are dependent on plasma membrane growth, which ensures that events of cell growth are coordinated with each other and with the cell cycle. However, the signals that link the cell cycle and ribosome biogenesis to membrane growth are poorly understood. Here we used proteome-wide mass spectrometry to systematically discover signals associated with membrane growth. The results suggest that membrane trafficking events required for membrane growth generate sphingolipid-dependent signals. A conserved signaling network appears to play an essential role in signaling by responding to delivery of sphingolipids to the plasma membrane. In addition, sphingolipid-dependent signals control phosphorylation of protein kinase C (Pkc1), which plays an essential role in the pathways that link the cell cycle and ribosome biogenesis to membrane growth. Together these discoveries provide new clues as to how growth-­dependent signals control cell growth and the cell cycle. The American Society for Cell Biology 2017-10-01 /pmc/articles/PMC5620368/ /pubmed/28794263 http://dx.doi.org/10.1091/mbc.E17-01-0081 Text en © 2017 Clarke et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle Brief Reports
Clarke, Jesse
Dephoure, Noah
Horecka, Ira
Gygi, Steven
Kellogg, Douglas
A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
title A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
title_full A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
title_fullStr A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
title_full_unstemmed A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
title_short A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
title_sort conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620368/
https://www.ncbi.nlm.nih.gov/pubmed/28794263
http://dx.doi.org/10.1091/mbc.E17-01-0081
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