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A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
In budding yeast, cell cycle progression and ribosome biogenesis are dependent on plasma membrane growth, which ensures that events of cell growth are coordinated with each other and with the cell cycle. However, the signals that link the cell cycle and ribosome biogenesis to membrane growth are poo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620368/ https://www.ncbi.nlm.nih.gov/pubmed/28794263 http://dx.doi.org/10.1091/mbc.E17-01-0081 |
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author | Clarke, Jesse Dephoure, Noah Horecka, Ira Gygi, Steven Kellogg, Douglas |
author_facet | Clarke, Jesse Dephoure, Noah Horecka, Ira Gygi, Steven Kellogg, Douglas |
author_sort | Clarke, Jesse |
collection | PubMed |
description | In budding yeast, cell cycle progression and ribosome biogenesis are dependent on plasma membrane growth, which ensures that events of cell growth are coordinated with each other and with the cell cycle. However, the signals that link the cell cycle and ribosome biogenesis to membrane growth are poorly understood. Here we used proteome-wide mass spectrometry to systematically discover signals associated with membrane growth. The results suggest that membrane trafficking events required for membrane growth generate sphingolipid-dependent signals. A conserved signaling network appears to play an essential role in signaling by responding to delivery of sphingolipids to the plasma membrane. In addition, sphingolipid-dependent signals control phosphorylation of protein kinase C (Pkc1), which plays an essential role in the pathways that link the cell cycle and ribosome biogenesis to membrane growth. Together these discoveries provide new clues as to how growth-dependent signals control cell growth and the cell cycle. |
format | Online Article Text |
id | pubmed-5620368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-56203682017-12-16 A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast Clarke, Jesse Dephoure, Noah Horecka, Ira Gygi, Steven Kellogg, Douglas Mol Biol Cell Brief Reports In budding yeast, cell cycle progression and ribosome biogenesis are dependent on plasma membrane growth, which ensures that events of cell growth are coordinated with each other and with the cell cycle. However, the signals that link the cell cycle and ribosome biogenesis to membrane growth are poorly understood. Here we used proteome-wide mass spectrometry to systematically discover signals associated with membrane growth. The results suggest that membrane trafficking events required for membrane growth generate sphingolipid-dependent signals. A conserved signaling network appears to play an essential role in signaling by responding to delivery of sphingolipids to the plasma membrane. In addition, sphingolipid-dependent signals control phosphorylation of protein kinase C (Pkc1), which plays an essential role in the pathways that link the cell cycle and ribosome biogenesis to membrane growth. Together these discoveries provide new clues as to how growth-dependent signals control cell growth and the cell cycle. The American Society for Cell Biology 2017-10-01 /pmc/articles/PMC5620368/ /pubmed/28794263 http://dx.doi.org/10.1091/mbc.E17-01-0081 Text en © 2017 Clarke et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. |
spellingShingle | Brief Reports Clarke, Jesse Dephoure, Noah Horecka, Ira Gygi, Steven Kellogg, Douglas A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast |
title | A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast |
title_full | A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast |
title_fullStr | A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast |
title_full_unstemmed | A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast |
title_short | A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast |
title_sort | conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620368/ https://www.ncbi.nlm.nih.gov/pubmed/28794263 http://dx.doi.org/10.1091/mbc.E17-01-0081 |
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