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Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

Synaptopathy underlying memory deficits in Alzheimer’s disease (AD) is increasingly thought to be instigated by toxic oligomers of the amyloid beta peptide (AβOs). Given the long latency and incomplete penetrance of AD dementia with respect to Aβ pathology, we hypothesized that factors present in th...

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Detalles Bibliográficos
Autores principales:	Pitt, Jason, Wilcox, Kyle C., Tortelli, Vanessa, Diniz, Luan Pereira, Oliveira, Maira S., Dobbins, Cassandra, Yu, Xiao-Wen, Nandamuri, Sathwik, Gomes, Flávia C. A., DiNunno, Nadia, Viola, Kirsten L., De Felice, Fernanda G., Ferreira, Sergio T., Klein, William L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620371/ https://www.ncbi.nlm.nih.gov/pubmed/28963439 http://dx.doi.org/10.1091/mbc.E17-06-0416

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