Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects

Phenytoin (PHT) oxidative route leads to its main metabolite p-hydroxyphenytoin (p-HPPH), by means of CYP2C9 and CYP2C19. Formation of p-HPPH proceeds via a reactive arene-oxide intermediate. This intermediate can also be converted into PHT dihydrodiol by microsomal epoxide hydrolase (EPHX). The thr...

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Detalles Bibliográficos
Autores principales: Guevara, Natalia, Maldonado, Cecilia, Uría, Manuel, González, Raquel, Ibarra, Manuel, Alvariza, Silvana, Carozzi, Antonella, Azambuja, Carlos, Fagiolino, Pietro, Vázquez, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620617/
https://www.ncbi.nlm.nih.gov/pubmed/28820457
http://dx.doi.org/10.3390/ph10030073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620617/
https://www.ncbi.nlm.nih.gov/pubmed/28820457
http://dx.doi.org/10.3390/ph10030073

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