(18)F-Deoxyfluorination of Phenols via Ru π-Complexes

[Image: see text] The deficiency of robust and practical methods for (18)F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted (18)F-deoxyfluorination of phenols. The transformation benefits from readily ava...

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Detalles Bibliográficos
Autores principales: Beyzavi, M. Hassan, Mandal, Debashis, Strebl, Martin G., Neumann, Constanze N., D’Amato, Erica M., Chen, Junting, Hooker, Jacob M., Ritter, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621004/
https://www.ncbi.nlm.nih.gov/pubmed/28979935
http://dx.doi.org/10.1021/acscentsci.7b00195
Descripción
Sumario:[Image: see text] The deficiency of robust and practical methods for (18)F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted (18)F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.

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