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(18)F-Deoxyfluorination of Phenols via Ru π-Complexes
[Image: see text] The deficiency of robust and practical methods for (18)F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted (18)F-deoxyfluorination of phenols. The transformation benefits from readily ava...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621004/ https://www.ncbi.nlm.nih.gov/pubmed/28979935 http://dx.doi.org/10.1021/acscentsci.7b00195 |
| _version_ | 1783267665375133696 |
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| author | Beyzavi, M. Hassan Mandal, Debashis Strebl, Martin G. Neumann, Constanze N. D’Amato, Erica M. Chen, Junting Hooker, Jacob M. Ritter, Tobias |
| author_facet | Beyzavi, M. Hassan Mandal, Debashis Strebl, Martin G. Neumann, Constanze N. D’Amato, Erica M. Chen, Junting Hooker, Jacob M. Ritter, Tobias |
| author_sort | Beyzavi, M. Hassan |
| collection | PubMed |
| description | [Image: see text] The deficiency of robust and practical methods for (18)F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted (18)F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging. |
| format | Online Article Text |
| id | pubmed-5621004 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-56210042017-10-04 (18)F-Deoxyfluorination of Phenols via Ru π-Complexes Beyzavi, M. Hassan Mandal, Debashis Strebl, Martin G. Neumann, Constanze N. D’Amato, Erica M. Chen, Junting Hooker, Jacob M. Ritter, Tobias ACS Cent Sci [Image: see text] The deficiency of robust and practical methods for (18)F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted (18)F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging. American Chemical Society 2017-08-03 2017-09-27 /pmc/articles/PMC5621004/ /pubmed/28979935 http://dx.doi.org/10.1021/acscentsci.7b00195 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| spellingShingle | Beyzavi, M. Hassan Mandal, Debashis Strebl, Martin G. Neumann, Constanze N. D’Amato, Erica M. Chen, Junting Hooker, Jacob M. Ritter, Tobias (18)F-Deoxyfluorination of Phenols via Ru π-Complexes |
| title | (18)F-Deoxyfluorination of Phenols via Ru π-Complexes |
| title_full | (18)F-Deoxyfluorination of Phenols via Ru π-Complexes |
| title_fullStr | (18)F-Deoxyfluorination of Phenols via Ru π-Complexes |
| title_full_unstemmed | (18)F-Deoxyfluorination of Phenols via Ru π-Complexes |
| title_short | (18)F-Deoxyfluorination of Phenols via Ru π-Complexes |
| title_sort | (18)f-deoxyfluorination of phenols via ru π-complexes |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621004/ https://www.ncbi.nlm.nih.gov/pubmed/28979935 http://dx.doi.org/10.1021/acscentsci.7b00195 |
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