BRCA1-mutated ovarian cancer with skin metastasis: a case report

The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, informa...

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Autores principales: Oh, So Ra, Park, Jung-Woo, Kwon, Hyun Young, Rha, Seo-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621079/
https://www.ncbi.nlm.nih.gov/pubmed/28989926
http://dx.doi.org/10.5468/ogs.2017.60.5.477
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author Oh, So Ra
Park, Jung-Woo
Kwon, Hyun Young
Rha, Seo-Hee
author_facet Oh, So Ra
Park, Jung-Woo
Kwon, Hyun Young
Rha, Seo-Hee
author_sort Oh, So Ra
collection PubMed
description The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.
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spelling pubmed-56210792017-10-06 BRCA1-mutated ovarian cancer with skin metastasis: a case report Oh, So Ra Park, Jung-Woo Kwon, Hyun Young Rha, Seo-Hee Obstet Gynecol Sci Case Report The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2017-09 2017-09-18 /pmc/articles/PMC5621079/ /pubmed/28989926 http://dx.doi.org/10.5468/ogs.2017.60.5.477 Text en Copyright © 2017 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Oh, So Ra
Park, Jung-Woo
Kwon, Hyun Young
Rha, Seo-Hee
BRCA1-mutated ovarian cancer with skin metastasis: a case report
title BRCA1-mutated ovarian cancer with skin metastasis: a case report
title_full BRCA1-mutated ovarian cancer with skin metastasis: a case report
title_fullStr BRCA1-mutated ovarian cancer with skin metastasis: a case report
title_full_unstemmed BRCA1-mutated ovarian cancer with skin metastasis: a case report
title_short BRCA1-mutated ovarian cancer with skin metastasis: a case report
title_sort brca1-mutated ovarian cancer with skin metastasis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621079/
https://www.ncbi.nlm.nih.gov/pubmed/28989926
http://dx.doi.org/10.5468/ogs.2017.60.5.477
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