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Recent advances in eosinophilic esophagitis
Eosinophilic esophagitis is a chronic, antigen-driven, eosinophil-predominant inflammatory disease of the esophagus and affects both children and adults. Cutting-edge technologies, such as genome-wide association studies, have advanced our understanding of the disease pathogenesis at a remarkable ra...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621107/ https://www.ncbi.nlm.nih.gov/pubmed/29043074 http://dx.doi.org/10.12688/f1000research.11798.1 |
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author | Durrani, Sandy Rothenberg, Marc |
author_facet | Durrani, Sandy Rothenberg, Marc |
author_sort | Durrani, Sandy |
collection | PubMed |
description | Eosinophilic esophagitis is a chronic, antigen-driven, eosinophil-predominant inflammatory disease of the esophagus and affects both children and adults. Cutting-edge technologies, such as genome-wide association studies, have advanced our understanding of the disease pathogenesis at a remarkable rate. Recent insights from genetic and mechanistic studies have concluded that a complex interplay between genetic and environmental risk factors, allergic sensitization, and esophageal-specific pathways leads to disease pathogenesis. Importantly, recent epidemiologic studies have found that the incidence and prevalence of eosinophilic esophagitis continue to rise. New guidelines have advocated the elimination of the term proton pump inhibitor (PPI)–responsive esophageal eosinophilia and have recommended using PPIs as a first-line treatment modality. Systemic reviews and meta-analyses confirm the efficacy of PPIs, topical corticosteroids, and empiric food elimination diets. Unmet needs include the development of birth cohort studies, validated diagnostic scoring systems, minimally invasive disease-monitoring methods, and the development of new therapies. |
format | Online Article Text |
id | pubmed-5621107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-56211072017-10-16 Recent advances in eosinophilic esophagitis Durrani, Sandy Rothenberg, Marc F1000Res Review Eosinophilic esophagitis is a chronic, antigen-driven, eosinophil-predominant inflammatory disease of the esophagus and affects both children and adults. Cutting-edge technologies, such as genome-wide association studies, have advanced our understanding of the disease pathogenesis at a remarkable rate. Recent insights from genetic and mechanistic studies have concluded that a complex interplay between genetic and environmental risk factors, allergic sensitization, and esophageal-specific pathways leads to disease pathogenesis. Importantly, recent epidemiologic studies have found that the incidence and prevalence of eosinophilic esophagitis continue to rise. New guidelines have advocated the elimination of the term proton pump inhibitor (PPI)–responsive esophageal eosinophilia and have recommended using PPIs as a first-line treatment modality. Systemic reviews and meta-analyses confirm the efficacy of PPIs, topical corticosteroids, and empiric food elimination diets. Unmet needs include the development of birth cohort studies, validated diagnostic scoring systems, minimally invasive disease-monitoring methods, and the development of new therapies. F1000Research 2017-09-28 /pmc/articles/PMC5621107/ /pubmed/29043074 http://dx.doi.org/10.12688/f1000research.11798.1 Text en Copyright: © 2017 Durrani S and Rothenberg M http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Durrani, Sandy Rothenberg, Marc Recent advances in eosinophilic esophagitis |
title | Recent advances in eosinophilic esophagitis |
title_full | Recent advances in eosinophilic esophagitis |
title_fullStr | Recent advances in eosinophilic esophagitis |
title_full_unstemmed | Recent advances in eosinophilic esophagitis |
title_short | Recent advances in eosinophilic esophagitis |
title_sort | recent advances in eosinophilic esophagitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621107/ https://www.ncbi.nlm.nih.gov/pubmed/29043074 http://dx.doi.org/10.12688/f1000research.11798.1 |
work_keys_str_mv | AT durranisandy recentadvancesineosinophilicesophagitis AT rothenbergmarc recentadvancesineosinophilicesophagitis |