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Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study

PURPOSE: The aim of this study was to evaluate risk factors in patients with macular telangiectasia (MacTel) 2A in an Asian population. This was a hospital-based case–control study. METHODS: We reviewed the case records of patients in our hospital, diagnosed as MacTel 2A over a 3-year period from Ap...

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Autores principales: Elias, Anna, Gopalakrishnan, Mahesh, Anantharaman, Giridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621265/
https://www.ncbi.nlm.nih.gov/pubmed/28905826
http://dx.doi.org/10.4103/ijo.IJO_85_17
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author Elias, Anna
Gopalakrishnan, Mahesh
Anantharaman, Giridhar
author_facet Elias, Anna
Gopalakrishnan, Mahesh
Anantharaman, Giridhar
author_sort Elias, Anna
collection PubMed
description PURPOSE: The aim of this study was to evaluate risk factors in patients with macular telangiectasia (MacTel) 2A in an Asian population. This was a hospital-based case–control study. METHODS: We reviewed the case records of patients in our hospital, diagnosed as MacTel 2A over a 3-year period from April 2011 to March 2014. Controls were selected from patients seen in the hospital at the same time for visual defects after matching for age and sex. A multivariate logistic regression model was constructed using the variables that showed a statistically significant association (P < 0.05) with MacTel 2A in the univariate analysis. RESULTS: The mean age of the patients with MacTel 2A was 58.63 years. A majority (76; 73.8%) of the patients were female. Of the patients with MacTel 2A, 61 (59.2%) patients had diabetes mellitus, and 50 (48.5%) revealed hypertension. Multivariate logistic regression analysis revealed the presence of diabetes mellitus to be the risk factor with the highest odds ratio (OR) of 5.7 followed by hypertension with an OR of 2.6. Binary logistic regression showed hypermetropia to have a greater risk factor compared to emmetropia, OR 2.64. CONCLUSION: Our case–control study revealed that MacTel 2A is significantly associated with systemic diseases. Diabetes mellitus was found to have the strongest association with MacTel 2A, showing a high OR of 5.7. Systemic hypertension followed by an OR of 2.6. Compared to emmetropia, hypermetropia was significantly associated with MacTel 2A. There could be a genetic link between the two. Determining risk factors draws us close to the goal of identifying the etiopathogenesis of MacTel 2A.
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spelling pubmed-56212652017-10-04 Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study Elias, Anna Gopalakrishnan, Mahesh Anantharaman, Giridhar Indian J Ophthalmol Original Article PURPOSE: The aim of this study was to evaluate risk factors in patients with macular telangiectasia (MacTel) 2A in an Asian population. This was a hospital-based case–control study. METHODS: We reviewed the case records of patients in our hospital, diagnosed as MacTel 2A over a 3-year period from April 2011 to March 2014. Controls were selected from patients seen in the hospital at the same time for visual defects after matching for age and sex. A multivariate logistic regression model was constructed using the variables that showed a statistically significant association (P < 0.05) with MacTel 2A in the univariate analysis. RESULTS: The mean age of the patients with MacTel 2A was 58.63 years. A majority (76; 73.8%) of the patients were female. Of the patients with MacTel 2A, 61 (59.2%) patients had diabetes mellitus, and 50 (48.5%) revealed hypertension. Multivariate logistic regression analysis revealed the presence of diabetes mellitus to be the risk factor with the highest odds ratio (OR) of 5.7 followed by hypertension with an OR of 2.6. Binary logistic regression showed hypermetropia to have a greater risk factor compared to emmetropia, OR 2.64. CONCLUSION: Our case–control study revealed that MacTel 2A is significantly associated with systemic diseases. Diabetes mellitus was found to have the strongest association with MacTel 2A, showing a high OR of 5.7. Systemic hypertension followed by an OR of 2.6. Compared to emmetropia, hypermetropia was significantly associated with MacTel 2A. There could be a genetic link between the two. Determining risk factors draws us close to the goal of identifying the etiopathogenesis of MacTel 2A. Medknow Publications & Media Pvt Ltd 2017-09 /pmc/articles/PMC5621265/ /pubmed/28905826 http://dx.doi.org/10.4103/ijo.IJO_85_17 Text en Copyright: © 2017 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Elias, Anna
Gopalakrishnan, Mahesh
Anantharaman, Giridhar
Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study
title Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study
title_full Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study
title_fullStr Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study
title_full_unstemmed Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study
title_short Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study
title_sort risk factors in patients with macular telangiectasia 2a in an asian population: a case–control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621265/
https://www.ncbi.nlm.nih.gov/pubmed/28905826
http://dx.doi.org/10.4103/ijo.IJO_85_17
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