Synthesis and evaluation of MR probes for targeted-reporter imaging

Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable f...

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Detalles Bibliográficos
Autores principales: Verma, Kirti Dhingra, Massing, Justin O., Kamper, Sarah G., Carney, Christiane E., MacRenaris, Keith W., Basilion, James P., Meade, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621504/
https://www.ncbi.nlm.nih.gov/pubmed/28989616
http://dx.doi.org/10.1039/c7sc02217d
Descripción
Sumario:Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable for subsequent targeted-reporter imaging applications.

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