Synthesis and evaluation of MR probes for targeted-reporter imaging

Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable f...

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Detalles Bibliográficos
Autores principales: Verma, Kirti Dhingra, Massing, Justin O., Kamper, Sarah G., Carney, Christiane E., MacRenaris, Keith W., Basilion, James P., Meade, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621504/
https://www.ncbi.nlm.nih.gov/pubmed/28989616
http://dx.doi.org/10.1039/c7sc02217d
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author Verma, Kirti Dhingra
Massing, Justin O.
Kamper, Sarah G.
Carney, Christiane E.
MacRenaris, Keith W.
Basilion, James P.
Meade, Thomas J.
author_facet Verma, Kirti Dhingra
Massing, Justin O.
Kamper, Sarah G.
Carney, Christiane E.
MacRenaris, Keith W.
Basilion, James P.
Meade, Thomas J.
author_sort Verma, Kirti Dhingra
collection PubMed
description Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable for subsequent targeted-reporter imaging applications.
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spelling pubmed-56215042017-10-06 Synthesis and evaluation of MR probes for targeted-reporter imaging Verma, Kirti Dhingra Massing, Justin O. Kamper, Sarah G. Carney, Christiane E. MacRenaris, Keith W. Basilion, James P. Meade, Thomas J. Chem Sci Chemistry Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable for subsequent targeted-reporter imaging applications. Royal Society of Chemistry 2017-08-01 2017-06-13 /pmc/articles/PMC5621504/ /pubmed/28989616 http://dx.doi.org/10.1039/c7sc02217d Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Verma, Kirti Dhingra
Massing, Justin O.
Kamper, Sarah G.
Carney, Christiane E.
MacRenaris, Keith W.
Basilion, James P.
Meade, Thomas J.
Synthesis and evaluation of MR probes for targeted-reporter imaging
title Synthesis and evaluation of MR probes for targeted-reporter imaging
title_full Synthesis and evaluation of MR probes for targeted-reporter imaging
title_fullStr Synthesis and evaluation of MR probes for targeted-reporter imaging
title_full_unstemmed Synthesis and evaluation of MR probes for targeted-reporter imaging
title_short Synthesis and evaluation of MR probes for targeted-reporter imaging
title_sort synthesis and evaluation of mr probes for targeted-reporter imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621504/
https://www.ncbi.nlm.nih.gov/pubmed/28989616
http://dx.doi.org/10.1039/c7sc02217d
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