The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evide...

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Autores principales: Gradowski, Marcin, Pawłowski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621508/
https://www.ncbi.nlm.nih.gov/pubmed/28966893
http://dx.doi.org/10.7717/peerj.3849
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author Gradowski, Marcin
Pawłowski, Krzysztof
author_facet Gradowski, Marcin
Pawłowski, Krzysztof
author_sort Gradowski, Marcin
collection PubMed
description Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.
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spelling pubmed-56215082017-09-29 The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases Gradowski, Marcin Pawłowski, Krzysztof PeerJ Bioinformatics Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results. PeerJ Inc. 2017-09-26 /pmc/articles/PMC5621508/ /pubmed/28966893 http://dx.doi.org/10.7717/peerj.3849 Text en ©2017 Gradowski and Pawłowski http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioinformatics
Gradowski, Marcin
Pawłowski, Krzysztof
The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
title The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
title_full The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
title_fullStr The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
title_full_unstemmed The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
title_short The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
title_sort legionella pneumophila effector lpg1137 is a homologue of mitochondrial slc25 carrier proteins, not of known serine proteases
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621508/
https://www.ncbi.nlm.nih.gov/pubmed/28966893
http://dx.doi.org/10.7717/peerj.3849
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