Metabolic gatekeeper function of B-lymphoid transcription factors

B-lymphoid transcription factors (e.g. PAX5, IKZF1) are critical for early B-cell development(1–2), yet genetic lesions occur in >80% of cases of B-cell acute lymphoblastic leukemia (ALL)(3–4). The significance of these lesions in ALL remained unclear. Combining ChIP-seq and RNA-seq studies, we i...

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Detalles Bibliográficos
Autores principales: Chan, Lai N., Chen, Zhengshan, Braas, Daniel, Lee, Jae-Woong, Xiao, Gang, Geng, Huimin, Cosgun, Kadriye Nehir, Hurtz, Christian, Shojaee, Seyedmehdi, Cazzaniga, Valeria, Schjerven, Hilde, Ernst, Thomas, Hochhaus, Andreas, Kornblau, Steven M., Konopleva, Marina, Pufall, Miles A., Cazzaniga, Giovanni, Liu, Grace J., Milne, Thomas A., Koeffler, H. Philip, Ross, Theodora S., Sanchez-Garcia, Isidro, Borkhardt, Arndt, Yamamoto, Keith R., Dickins, Ross A., Graeber, Thomas G., Müschen, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621518/
https://www.ncbi.nlm.nih.gov/pubmed/28192788
http://dx.doi.org/10.1038/nature21076

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