Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this t...

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Detalles Bibliográficos
Autores principales: Maryandyshev, Andrey, Pontali, Emanuele, Tiberi, Simon, Akkerman, Onno, Ganatra, Shashank, Sadutshang, Tsetan Dorji, Alffenaar, Jan-Willem, Amale, Rohit, Mullerpattan, Jai, Topgyal, Sonam, Udwadia, Zarir Farokh, Centis, Rosella, D’Ambrosio, Lia, Sotgiu, Giovanni, Migliori, Giovanni Battista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621558/
https://www.ncbi.nlm.nih.gov/pubmed/28758888
http://dx.doi.org/10.3201/eid2310.170834
Descripción
Sumario:We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.

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