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Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this t...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Centers for Disease Control and Prevention
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621558/ https://www.ncbi.nlm.nih.gov/pubmed/28758888 http://dx.doi.org/10.3201/eid2310.170834 |
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| author | Maryandyshev, Andrey Pontali, Emanuele Tiberi, Simon Akkerman, Onno Ganatra, Shashank Sadutshang, Tsetan Dorji Alffenaar, Jan-Willem Amale, Rohit Mullerpattan, Jai Topgyal, Sonam Udwadia, Zarir Farokh Centis, Rosella D’Ambrosio, Lia Sotgiu, Giovanni Migliori, Giovanni Battista |
| author_facet | Maryandyshev, Andrey Pontali, Emanuele Tiberi, Simon Akkerman, Onno Ganatra, Shashank Sadutshang, Tsetan Dorji Alffenaar, Jan-Willem Amale, Rohit Mullerpattan, Jai Topgyal, Sonam Udwadia, Zarir Farokh Centis, Rosella D’Ambrosio, Lia Sotgiu, Giovanni Migliori, Giovanni Battista |
| author_sort | Maryandyshev, Andrey |
| collection | PubMed |
| description | We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options. |
| format | Online Article Text |
| id | pubmed-5621558 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Centers for Disease Control and Prevention |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-56215582017-10-07 Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis Maryandyshev, Andrey Pontali, Emanuele Tiberi, Simon Akkerman, Onno Ganatra, Shashank Sadutshang, Tsetan Dorji Alffenaar, Jan-Willem Amale, Rohit Mullerpattan, Jai Topgyal, Sonam Udwadia, Zarir Farokh Centis, Rosella D’Ambrosio, Lia Sotgiu, Giovanni Migliori, Giovanni Battista Emerg Infect Dis Dispatch We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options. Centers for Disease Control and Prevention 2017-10 /pmc/articles/PMC5621558/ /pubmed/28758888 http://dx.doi.org/10.3201/eid2310.170834 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
| spellingShingle | Dispatch Maryandyshev, Andrey Pontali, Emanuele Tiberi, Simon Akkerman, Onno Ganatra, Shashank Sadutshang, Tsetan Dorji Alffenaar, Jan-Willem Amale, Rohit Mullerpattan, Jai Topgyal, Sonam Udwadia, Zarir Farokh Centis, Rosella D’Ambrosio, Lia Sotgiu, Giovanni Migliori, Giovanni Battista Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_full | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_fullStr | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_full_unstemmed | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_short | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_sort | bedaquiline and delamanid combination treatment of 5 patients with pulmonary extensively drug-resistant tuberculosis |
| topic | Dispatch |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621558/ https://www.ncbi.nlm.nih.gov/pubmed/28758888 http://dx.doi.org/10.3201/eid2310.170834 |
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