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Clinical and molecular correlates in fragile X premutation females
The prevalence of the fragile X premutation (55–200 CGG repeats) among the general population is relatively high, but there remains a lack of clear understanding of the links between molecular biomarkers and clinical outcomes. In this study we investigated the correlations between molecular measures...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621595/ https://www.ncbi.nlm.nih.gov/pubmed/28971146 http://dx.doi.org/10.1016/j.ensci.2017.04.003 |
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author | Jiraanont, Poonnada Sweha, Stefan R. AlOlaby, Reem R. Silva, Marisol Tang, Hiu-Tung Durbin-Johnson, Blythe Schneider, Andrea Espinal, Glenda M. Hagerman, Paul J. Rivera, Susan M. Hessl, David Hagerman, Randi J. Chutabhakdikul, Nuanchan Tassone, Flora |
author_facet | Jiraanont, Poonnada Sweha, Stefan R. AlOlaby, Reem R. Silva, Marisol Tang, Hiu-Tung Durbin-Johnson, Blythe Schneider, Andrea Espinal, Glenda M. Hagerman, Paul J. Rivera, Susan M. Hessl, David Hagerman, Randi J. Chutabhakdikul, Nuanchan Tassone, Flora |
author_sort | Jiraanont, Poonnada |
collection | PubMed |
description | The prevalence of the fragile X premutation (55–200 CGG repeats) among the general population is relatively high, but there remains a lack of clear understanding of the links between molecular biomarkers and clinical outcomes. In this study we investigated the correlations between molecular measures (CGG repeat size, FMR1 mRNA, FMRP expression levels, and methylation status at the promoter region and in FREE2 site) and clinical phenotypes (anxiety, obsessive compulsive symptoms, depression and executive function deficits) in 36 adult premutation female carriers and compared to 24 normal control subjects. Premutation carriers reported higher levels of obsessive compulsive symptoms, depression, and anxiety, but demonstrated no significant deficits in global cognitive functions or executive function compared to the control group. Increased age in carriers was significantly associated with increased anxiety levels. As expected, FMR1 mRNA expression was significantly correlated with CGG repeat number. However, no significant correlations were observed between molecular (including epigenetic) measures and clinical phenotypes in this sample. Our study, albeit limited by the sample size, establishes the complexity of the mechanisms that link the FMR1 locus to the clinical phenotypes commonly observed in female carriers suggesting that other factors, including environment or additional genetic changes, may have an impact on the clinical phenotypes. However, it continues to emphasize the need for assessment and treatment of psychiatric problems in female premutation carriers. |
format | Online Article Text |
id | pubmed-5621595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56215952017-12-19 Clinical and molecular correlates in fragile X premutation females Jiraanont, Poonnada Sweha, Stefan R. AlOlaby, Reem R. Silva, Marisol Tang, Hiu-Tung Durbin-Johnson, Blythe Schneider, Andrea Espinal, Glenda M. Hagerman, Paul J. Rivera, Susan M. Hessl, David Hagerman, Randi J. Chutabhakdikul, Nuanchan Tassone, Flora eNeurologicalSci Original Article The prevalence of the fragile X premutation (55–200 CGG repeats) among the general population is relatively high, but there remains a lack of clear understanding of the links between molecular biomarkers and clinical outcomes. In this study we investigated the correlations between molecular measures (CGG repeat size, FMR1 mRNA, FMRP expression levels, and methylation status at the promoter region and in FREE2 site) and clinical phenotypes (anxiety, obsessive compulsive symptoms, depression and executive function deficits) in 36 adult premutation female carriers and compared to 24 normal control subjects. Premutation carriers reported higher levels of obsessive compulsive symptoms, depression, and anxiety, but demonstrated no significant deficits in global cognitive functions or executive function compared to the control group. Increased age in carriers was significantly associated with increased anxiety levels. As expected, FMR1 mRNA expression was significantly correlated with CGG repeat number. However, no significant correlations were observed between molecular (including epigenetic) measures and clinical phenotypes in this sample. Our study, albeit limited by the sample size, establishes the complexity of the mechanisms that link the FMR1 locus to the clinical phenotypes commonly observed in female carriers suggesting that other factors, including environment or additional genetic changes, may have an impact on the clinical phenotypes. However, it continues to emphasize the need for assessment and treatment of psychiatric problems in female premutation carriers. Elsevier 2017-04-11 /pmc/articles/PMC5621595/ /pubmed/28971146 http://dx.doi.org/10.1016/j.ensci.2017.04.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Jiraanont, Poonnada Sweha, Stefan R. AlOlaby, Reem R. Silva, Marisol Tang, Hiu-Tung Durbin-Johnson, Blythe Schneider, Andrea Espinal, Glenda M. Hagerman, Paul J. Rivera, Susan M. Hessl, David Hagerman, Randi J. Chutabhakdikul, Nuanchan Tassone, Flora Clinical and molecular correlates in fragile X premutation females |
title | Clinical and molecular correlates in fragile X premutation females |
title_full | Clinical and molecular correlates in fragile X premutation females |
title_fullStr | Clinical and molecular correlates in fragile X premutation females |
title_full_unstemmed | Clinical and molecular correlates in fragile X premutation females |
title_short | Clinical and molecular correlates in fragile X premutation females |
title_sort | clinical and molecular correlates in fragile x premutation females |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621595/ https://www.ncbi.nlm.nih.gov/pubmed/28971146 http://dx.doi.org/10.1016/j.ensci.2017.04.003 |
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