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Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice

Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major sleep-regulating factors. Cognitive and emotional factors also influence sleep–wake behaviour; however, the precise circuit mechanisms underlying their effe...

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Autores principales: Oishi, Yo, Xu, Qi, Wang, Lu, Zhang, Bin-Jia, Takahashi, Koji, Takata, Yohko, Luo, Yan-Jia, Cherasse, Yoan, Schiffmann, Serge N., de Kerchove d’Exaerde, Alban, Urade, Yoshihiro, Qu, Wei-Min, Huang, Zhi-Li, Lazarus, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622037/
https://www.ncbi.nlm.nih.gov/pubmed/28963505
http://dx.doi.org/10.1038/s41467-017-00781-4
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author Oishi, Yo
Xu, Qi
Wang, Lu
Zhang, Bin-Jia
Takahashi, Koji
Takata, Yohko
Luo, Yan-Jia
Cherasse, Yoan
Schiffmann, Serge N.
de Kerchove d’Exaerde, Alban
Urade, Yoshihiro
Qu, Wei-Min
Huang, Zhi-Li
Lazarus, Michael
author_facet Oishi, Yo
Xu, Qi
Wang, Lu
Zhang, Bin-Jia
Takahashi, Koji
Takata, Yohko
Luo, Yan-Jia
Cherasse, Yoan
Schiffmann, Serge N.
de Kerchove d’Exaerde, Alban
Urade, Yoshihiro
Qu, Wei-Min
Huang, Zhi-Li
Lazarus, Michael
author_sort Oishi, Yo
collection PubMed
description Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major sleep-regulating factors. Cognitive and emotional factors also influence sleep–wake behaviour; however, the precise circuit mechanisms underlying their effects on sleep control are unknown. Previous studies suggest that adenosine has a role affecting behavioural arousal in the nucleus accumbens (NAc), a brain area critical for reinforcement and reward. Here, we show that chemogenetic or optogenetic activation of excitatory adenosine A(2A) receptor-expressing indirect pathway neurons in the core region of the NAc strongly induces slow-wave sleep. Chemogenetic inhibition of the NAc indirect pathway neurons prevents the sleep induction, but does not affect the homoeostatic sleep rebound. In addition, motivational stimuli inhibit the activity of ventral pallidum-projecting NAc indirect pathway neurons and suppress sleep. Our findings reveal a prominent contribution of this indirect pathway to sleep control associated with motivation.
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spelling pubmed-56220372017-10-02 Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice Oishi, Yo Xu, Qi Wang, Lu Zhang, Bin-Jia Takahashi, Koji Takata, Yohko Luo, Yan-Jia Cherasse, Yoan Schiffmann, Serge N. de Kerchove d’Exaerde, Alban Urade, Yoshihiro Qu, Wei-Min Huang, Zhi-Li Lazarus, Michael Nat Commun Article Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major sleep-regulating factors. Cognitive and emotional factors also influence sleep–wake behaviour; however, the precise circuit mechanisms underlying their effects on sleep control are unknown. Previous studies suggest that adenosine has a role affecting behavioural arousal in the nucleus accumbens (NAc), a brain area critical for reinforcement and reward. Here, we show that chemogenetic or optogenetic activation of excitatory adenosine A(2A) receptor-expressing indirect pathway neurons in the core region of the NAc strongly induces slow-wave sleep. Chemogenetic inhibition of the NAc indirect pathway neurons prevents the sleep induction, but does not affect the homoeostatic sleep rebound. In addition, motivational stimuli inhibit the activity of ventral pallidum-projecting NAc indirect pathway neurons and suppress sleep. Our findings reveal a prominent contribution of this indirect pathway to sleep control associated with motivation. Nature Publishing Group UK 2017-09-29 /pmc/articles/PMC5622037/ /pubmed/28963505 http://dx.doi.org/10.1038/s41467-017-00781-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Oishi, Yo
Xu, Qi
Wang, Lu
Zhang, Bin-Jia
Takahashi, Koji
Takata, Yohko
Luo, Yan-Jia
Cherasse, Yoan
Schiffmann, Serge N.
de Kerchove d’Exaerde, Alban
Urade, Yoshihiro
Qu, Wei-Min
Huang, Zhi-Li
Lazarus, Michael
Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
title Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
title_full Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
title_fullStr Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
title_full_unstemmed Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
title_short Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
title_sort slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622037/
https://www.ncbi.nlm.nih.gov/pubmed/28963505
http://dx.doi.org/10.1038/s41467-017-00781-4
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