Cargando…

Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer’s disease-like pathologies

Recent studies on neurodegeneration have focused on dysfunction of CNS energy metabolism as well as proteinopathies. Adiponectin (ADPN), an adipocyte-derived hormone, plays a major role in the regulation of insulin sensitivity and glucose homeostasis in peripheral organs via adiponectin receptors. I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Min Woo, Abid, Noman bin, Jo, Myeong Hoon, Jo, Min Gi, Yoon, Gwang Ho, Kim, Myeong Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622055/ https://www.ncbi.nlm.nih.gov/pubmed/28963462 http://dx.doi.org/10.1038/s41598-017-12632-9

Ejemplares similares

Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain
por: Hahm, Jong Ryeal, et al.
Publicado: (2020)

Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer’s disease
por: Ali, Tahir, et al.
Publicado: (2021)

Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects
por: Ikram, Muhammad, et al.
Publicado: (2021)

Oral Administration of Alpha Linoleic Acid Rescues Aβ-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL/6N Mice
por: Ali, Waqar, et al.
Publicado: (2020)

Comparative Gene-Expression Analysis of Alzheimer’s Disease Progression with Aging in Transgenic Mouse Model
por: Abid, Noman Bin, et al.
Publicado: (2019)

A novel kit for early diagnosis of Alzheimer’s disease using a fluorescent nanoparticle imaging
por: Park, Jun Sung, et al.
Publicado: (2019)

LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain
por: Park, Jun Sung, et al.
Publicado: (2022)

Molecular Cloning and Expression of Osmotin in a Baculovirus-Insect System: Purified Osmotin Mitigates Amyloid-beta Deposition in Neuronal Cells
por: Abid, Noman Bin, et al.
Publicado: (2017)

17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway
por: Khan, Ibrahim, et al.
Publicado: (2021)

Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions
por: Ikram, Muhammad, et al.
Publicado: (2021)

Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ(1)–(42)-Induced Alzheimer’s Disease
por: Ahmad, Sareer, et al.
Publicado: (2021)

Pharmacological Inhibition of Spleen Tyrosine Kinase Suppressed Neuroinflammation and Cognitive Dysfunction in LPS-Induced Neurodegeneration Model
por: Kim, Min Woo, et al.
Publicado: (2022)

Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus
por: Ali, Tahir, et al.
Publicado: (2015)

Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling
por: Ikram, Muhammad, et al.
Publicado: (2019)

Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment
por: Ahmad, Sareer, et al.
Publicado: (2021)

Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain
por: Shah, Shahid Ali, et al.
Publicado: (2016)

New compounds identified through in silico approaches reduce the α-synuclein expression by inhibiting prolyl oligopeptidase in vitro
por: Kumar, Raj, et al.
Publicado: (2017)

Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation
por: He, Kaiwu, et al.
Publicado: (2021)

Pathology, Risk Factors, and Oxidative Damage Related to Type 2 Diabetes-Mediated Alzheimer's Disease and the Rescuing Effects of the Potent Antioxidant Anthocyanin
por: Khan, Muhammad Sohail, et al.
Publicado: (2021)

Gut Microbiota, Its Role in Induction of Alzheimer’s Disease Pathology, and Possible Therapeutic Interventions: Special Focus on Anthocyanins
por: Khan, Muhammad Sohail, et al.
Publicado: (2020)

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain
por: Ali, Tahir, et al.
Publicado: (2021)

Quinpirole-Mediated Regulation of Dopamine D2 Receptors Inhibits Glial Cell-Induced Neuroinflammation in Cortex and Striatum after Brain Injury
por: Alam, Sayed Ibrar, et al.
Publicado: (2021)

Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice
por: Yoo, Seul-Ki, et al.
Publicado: (2021)

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway
por: Badshah, Haroon, et al.
Publicado: (2016)

Glycine, the smallest amino acid, confers neuroprotection against d-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain
por: Ullah, Rahat, et al.
Publicado: (2020)

O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson’s Disease Mouse Models
por: Lee, Hyeon Jin, et al.
Publicado: (2022)

PIP-EL: A New Ensemble Learning Method for Improved Proinflammatory Peptide Predictions
por: Manavalan, Balachandran, et al.
Publicado: (2018)

Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
por: Hwang, Kyoung-Doo, et al.
Publicado: (2017)

Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy
por: Kim, Seok Gi, et al.
Publicado: (2023)

Exploring glia to better understand Alzheimer’s disease
por: Kim, Yoo Sung, et al.
Publicado: (2018)

Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodegeneration in an Amyloid-β-Induced Mouse Model
por: Saeed, Kamran, et al.
Publicado: (2020)

Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice
por: Ng, Roy Chun-Laam, et al.
Publicado: (2016)

Editorial: Natural Products-Based Drugs: Potential Therapeutics Against Alzheimer’s Disease and Other Neurological Disorders
por: Ayaz, Muhammad, et al.
Publicado: (2019)

Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the Role of Nrf-2 and A2AR Signaling
por: Ikram, Muhammad, et al.
Publicado: (2020)

Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment
por: Ahmad, Ashfaq, et al.
Publicado: (2019)

Establishing Co-Culture Blood–Brain Barrier Models for Different Neurodegeneration Conditions to Understand Its Effect on BBB Integrity
por: Park, Jun Sung, et al.
Publicado: (2023)

False Memory and Alzheimer's Disease Pathology in Patients with Amnestic Mild Cognitive Impairment: A Study with Amyloid PET
por: Choi, Eun-Ji, et al.
Publicado: (2021)

Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury
por: Park, Dong-Ju, et al.
Publicado: (2017)

iBCE-EL: A New Ensemble Learning Framework for Improved Linear B-Cell Epitope Prediction
por: Manavalan, Balachandran, et al.
Publicado: (2018)

Administration of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI Improves Cognitive and Memory Function in the Mouse Model of Alzheimer’s Disease
por: Kim, Hongwon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sfbjfaimpsvccsc4etqic1snda