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Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing
Excessive generation of amyloid-β peptide (Aβ) by aberrant proteolysis of amyloid precursor protein (APP) is a key event in Alzheimer's disease (AD) pathogenesis. FE65 is a brain-enriched phospho-adaptor protein that interacts with APP and has been shown to modulate APP processing. However, the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622059/ https://www.ncbi.nlm.nih.gov/pubmed/28963516 http://dx.doi.org/10.1038/s41598-017-12334-2 |