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Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing

Excessive generation of amyloid-β peptide (Aβ) by aberrant proteolysis of amyloid precursor protein (APP) is a key event in Alzheimer's disease (AD) pathogenesis. FE65 is a brain-enriched phospho-adaptor protein that interacts with APP and has been shown to modulate APP processing. However, the...

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Detalles Bibliográficos
Autores principales:	Lee, Yat Shing, Chow, Wan Ning Vanessa, Lau, Kwok-Fai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622059/ https://www.ncbi.nlm.nih.gov/pubmed/28963516 http://dx.doi.org/10.1038/s41598-017-12334-2

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