Cargando…

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, the pathophysiological significance of its activity is not well understood. Here, we demonstrate that the leucine sensor function for mTORC1 activation of LRS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jong Hyun, Lee, Chulho, Lee, Minji, Wang, Haipeng, Kim, Kibum, Park, Seung Joon, Yoon, Ina, Jang, Jayun, Zhao, Hanchao, Kim, Hoi Kyoung, Kwon, Nam Hoon, Jeong, Seung Jae, Yoo, Hee Chan, Kim, Jae Hyun, Yang, Jee Sun, Lee, Myeong Youl, Lee, Chang Woo, Yun, Jieun, Oh, Soo Jin, Kang, Jong Soon, Martinis, Susan A., Hwang, Kwang Yeon, Guo, Min, Han, Gyoonhee, Han, Jung Min, Kim, Sunghoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622079/ https://www.ncbi.nlm.nih.gov/pubmed/28963468 http://dx.doi.org/10.1038/s41467-017-00785-0

Ejemplares similares

Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer
por: Kim, Eun Young, et al.
Publicado: (2019)

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine
por: Kim, Kibum, et al.
Publicado: (2022)

Author Correction: O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine
por: Kim, Kibum, et al.
Publicado: (2022)

RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome
por: Sambri, Irene, et al.
Publicado: (2023)

Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity
por: Zhang, Yiwen, et al.
Publicado: (2021)

Leucyl-tRNA Synthetase Inhibitor, D-Norvaline, in Combination with Oxacillin, Is Effective against Methicillin-Resistant Staphylococcus aureus
por: Lee, Hong-Ju, et al.
Publicado: (2022)

RAG-1 and IgM Genes, Markers for Early Development of the Immune System in Olive Flounder, Paralichthys olivaceus
por: Lee, Jang-Wook, et al.
Publicado: (2014)

Development and characterization of a CRISPR/Cas9-mediated RAG1 knockout chicken model lacking mature B and T cells
por: Lee, Kyung Youn, et al.
Publicado: (2022)

Protocol for improving diffraction quality of leucyl-tRNA synthetase 1 with methylation and post-crystallization soaking and cooling in cryoprotectants
por: Kim, Sulhee, et al.
Publicado: (2021)

Rag2 Deficiency Enhances Susceptibility to Systemic Mouse Adenovirus Type 1 Infection
por: Lee, Han-Kyul, et al.
Publicado: (2021)

Altered Gut Microbiota Composition in Rag1-deficient Mice Contributes to Modulating Homeostasis of Hematopoietic Stem and Progenitor Cells
por: Kwon, Ohseop, et al.
Publicado: (2015)

Genotypic Distribution and Antimicrobial Susceptibilities of Carbapenemase-Producing Enterobacteriaceae Isolated From Rectal and Clinical Samples in Korean University Hospitals Between 2016 and 2019
por: Jeong, Seri, et al.
Publicado: (2022)

Impact of COVID-19 on Antimicrobial Consumption and Spread of Multidrug-Resistance in Bacterial Infections
por: Jeon, Kibum, et al.
Publicado: (2022)

The influence of gonadotropin-releasing hormone agonists on anthropometric change in girls with central precocious puberty
por: Yoon, Jong Wan, et al.
Publicado: (2017)

Molecular Diagnosis of Myoclonus Epilepsy Associated with Ragged-Red Fibers Syndrome in the Absence of Ragged Red Fibers
por: Park, Sun Yeong, et al.
Publicado: (2017)

Long-term outcomes of surgery for chronic thromboembolic pulmonary hypertension compared with medical therapy at a single Korean center
por: Kim, Soo Han, et al.
Publicado: (2017)

Possibility of Undifferentiated Human Thigh Adipose Stem Cells Differentiating into Functional Hepatocytes
por: Lee, Jong Hoon, et al.
Publicado: (2012)

Selective Unidirectional Saccadic Palsy Due to Cavernous Angioma in the Pontine Tegmentum
por: Kim, Jae-Myung, et al.
Publicado: (2019)

Endocrine comorbidities of pediatric obesity
por: Lee, Jieun, et al.
Publicado: (2021)

Three Cases of Non-Surgical Treatment of Stent Loss During Percutaneous Coronary Intervention
por: Shim, Byung-Ju, et al.
Publicado: (2010)

Neuroprotective and antioxidant activities of bamboo salt soy sauce against H(2)O(2)-induced oxidative stress in rat cortical neurons
por: JEONG, JONG HEE, et al.
Publicado: (2016)

Effect of Cerebral Small Vessel Disease Burden on Infarct Growth Rate and Stroke Outcomes in Large Vessel Occlusion Stroke Receiving Endovascular Treatment
por: Sohn, Jong-Hee, et al.
Publicado: (2023)

Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration
por: Jeong, Seung Jae, et al.
Publicado: (2018)

Investigation of Förster Resonance Energy Transfer (FRET) and Competition of Fluorescent Dyes on DNA Microparticles
por: Kim, Jieun, et al.
Publicado: (2015)

CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth
por: Choi, Sehee, et al.
Publicado: (2019)

β-Turn mimetic-based stabilizers of protein–protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase
por: Kim, Chanwoo, et al.
Publicado: (2016)

Return to Sports Activity After Reverse Total Shoulder Arthroplasty
por: Kim, Hyun Gon, et al.
Publicado: (2023)

Coagulopathy in patients who experience snakebite
por: Kim, Jae Seok, et al.
Publicado: (2008)

Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
por: Lee, Yeon-Ju, et al.
Publicado: (2017)

Comparison of the Novel Human Papillomavirus 4 Auto-capillary Electrophoresis Test with the Hybrid Capture 2 Assay and with the PCR HPV Typing Set Test in the Detection of High-Risk HPV Including HPV 16 and 18 Genotypes in Cervical Specimens
por: Hong, Jin Hwa, et al.
Publicado: (2009)

Air pollution and urinary n-acetyl-B-glucosaminidase levels in residents living near a cement plant
por: Jung, Min Soo, et al.
Publicado: (2016)

Comparison of body water status and its distribution in patients with non-septic infection, patients with sepsis, and healthy controls
por: Shin, Jieun, et al.
Publicado: (2021)

Deep Learning-Based Prediction of Paresthesia after Third Molar Extraction: A Preliminary Study
por: Kim, Byung Su, et al.
Publicado: (2021)

Dozens of Red Blood Cells in Cerebrospinal Fluid as a Diagnostic Clue to Spontaneous Vertebral Artery Dissection Mimicking Meningitis: Report of Two Cases
por: Kim, Hyung Jun, et al.
Publicado: (2020)

Genome of the Southern Giant Petrel Assembled Using Third-Generation DNA Sequencing and Linked Reads Reveals Evolutionary Traits of Southern Avian
por: Kim, Sun-Hee, et al.
Publicado: (2021)

Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of Natural Killer cell activity and early inflammatory response (Randomized, double-blinded, placebo-controlled trial)
por: Kwak, Jung Hyun, et al.
Publicado: (2012)

Transformation of Solid Waste into Nanoporous Carbon via Carbothermic Reduction
por: Kim, Chang Hyun, et al.
Publicado: (2018)

Structural dynamics of the aminoacylation and proof-reading functional cycle of bacterial leucyl-tRNA synthetase
por: Palencia, Andrés, et al.
Publicado: (2012)

Fracture Characteristics of Monolayer CVD-Graphene
por: Hwangbo, Yun, et al.
Publicado: (2014)

Indirect Volume Estimation for Acute Ischemic Stroke from Diffusion Weighted Image Using Slice Image Segmentation
por: Lee, Seung-Ah, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_as1anglq2dvg19874kmiihbohv