Cargando…

Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo

Synapses are an early pathological target in many neurodegenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson disease to neurodegenerative conditions of childhood such as spinal muscular atrophy (SMA) and neuronal ceroid lipofuscinosis (NCLs). However, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Llavero Hurtado, Maica, Fuller, Heidi R., Wong, Andrew M. S., Eaton, Samantha L., Gillingwater, Thomas H., Pennetta, Giuseppa, Cooper, Jonathan D., Wishart, Thomas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622084/ https://www.ncbi.nlm.nih.gov/pubmed/28963550 http://dx.doi.org/10.1038/s41598-017-12603-0

Ejemplares similares

Comparative proteomic profiling reveals mechanisms for early spinal cord vulnerability in CLN1 disease
por: Nelvagal, Hemanth R., et al.
Publicado: (2020)

Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture
por: Graham, Laura C., et al.
Publicado: (2017)

Total Protein Analysis as a Reliable Loading Control for Quantitative Fluorescent Western Blotting
por: Eaton, Samantha L., et al.
Publicado: (2013)

The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry
por: Fuller, Heidi R, et al.
Publicado: (2014)

A Guide to Modern Quantitative Fluorescent Western Blotting with Troubleshooting Strategies
por: Eaton, Samantha L., et al.
Publicado: (2014)

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
por: Hesse, Raphael, et al.
Publicado: (2019)

Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability
por: Graham, Laura C., et al.
Publicado: (2021)

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo
por: Wishart, Thomas M., et al.
Publicado: (2012)

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
por: Amorim, Inês S., et al.
Publicado: (2017)

Cellular and Molecular Anatomy of the Human Neuromuscular Junction
por: Jones, Ross A., et al.
Publicado: (2017)

Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration
por: Catenaccio, Alejandra, et al.
Publicado: (2017)

Proteomic Profiling of Cranial (Superior) Cervical Ganglia Reveals Beta-Amyloid and Ubiquitin Proteasome System Perturbations in an Equine Multiple System Neuropathy
por: McGorum, Bruce C., et al.
Publicado: (2015)

UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy
por: Shorrock, Hannah K, et al.
Publicado: (2018)

An Optimized Comparative Proteomic Approach as a Tool in Neurodegenerative Disease Research
por: Kline, Rachel A., et al.
Publicado: (2022)

Synaptic Protection in the Brain of Wld(S) Mice Occurs Independently of Age but Is Sensitive to Gene-Dose
por: Wright, Ann K., et al.
Publicado: (2010)

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease
por: Deguise, Marc-Olivier, et al.
Publicado: (2021)

Quantitative Proteomics of Synaptic and Nonsynaptic Mitochondria: Insights for Synaptic Mitochondrial Vulnerability
por: Stauch, Kelly L., et al.
Publicado: (2014)

Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wld(s))
por: Wishart, Thomas M, et al.
Publicado: (2008)

Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease
por: Kielar, Catherine, et al.
Publicado: (2009)

Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy
por: Mutsaers, Chantal A, et al.
Publicado: (2013)

Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex
por: Laszlo, Zsofia I., et al.
Publicado: (2022)

Pre-natal manifestation of systemic developmental abnormalities in spinal muscular atrophy
por: Motyl, Anna A L, et al.
Publicado: (2020)

Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA)
por: Šoltić, Darija, et al.
Publicado: (2018)

Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice
por: Kline, Rachel A., et al.
Publicado: (2019)

Insights into ALS pathomechanisms: from flies to humans
por: Chai, Andrea, et al.
Publicado: (2015)

Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins
por: Cijsouw, Tony, et al.
Publicado: (2018)

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy
por: Khan, Anzer, et al.
Publicado: (2020)

Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments
por: Goel, Pragya, et al.
Publicado: (2020)

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction
por: Sanhueza, Mario, et al.
Publicado: (2016)

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases
por: Kline, Rachel A., et al.
Publicado: (2017)

Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles
por: Sanhueza, Mario, et al.
Publicado: (2013)

Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging
por: Graham, Laura C., et al.
Publicado: (2019)

Mapping the Drivers of Climate Change Vulnerability for Australia’s Threatened Species
por: Lee, Jasmine R., et al.
Publicado: (2015)

Mapping Vulnerability
por: Bankoff, Greg
Publicado: (2013)

Distinct Synaptic Vesicle Proteomic Signatures Associated with Pre- and Post-Natal Oxycodone-Exposure
por: Odegaard, Katherine E., et al.
Publicado: (2022)

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction
por: Zhang, Dawei, et al.
Publicado: (2010)

Timing is everything: Clinical evidence supports pre-symptomatic treatment for spinal muscular atrophy
por: Motyl, Anna A.L., et al.
Publicado: (2022)

Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease
por: Carpanini, Sarah M, et al.
Publicado: (2017)

Pre-analytical stability of the plasma proteomes based on the storage temperature
por: Pasella, Sara, et al.
Publicado: (2013)

The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap
por: Brown, Sharon J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j3fbsqn5dfjiv7njaqohd4o8ln