Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and mediates the long duration of kappa opioid antidepressants by an uncharacterized, arrestin-independent mechanism. Here we use an iterative, discovery-based proteomic approach to show that following opioi...

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Detalles Bibliográficos
Autores principales: Schattauer, Selena S., Land, Benjamin B., Reichard, Kathryn L., Abraham, Antony D., Burgeno, Lauren M., Kuhar, Jamie R., Phillips, Paul E. M., Ong, Shao En, Chavkin, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622097/
https://www.ncbi.nlm.nih.gov/pubmed/28963507
http://dx.doi.org/10.1038/s41467-017-00791-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622097/
https://www.ncbi.nlm.nih.gov/pubmed/28963507
http://dx.doi.org/10.1038/s41467-017-00791-2

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