Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils

Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the joints of patients with RA. Calcium-dependent peptidyl-arginine deiminases (PAD) are the enzymes responsible for ci...

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Detalles Bibliográficos
Autores principales: Zhou, Yebin, Chen, Bo, Mittereder, Nanette, Chaerkady, Raghothama, Strain, Martin, An, Ling-Ling, Rahman, Saifur, Ma, Wenting, Low, Choon Pei, Chan, Denice, Neal, Frances, Bingham, Clifton O., Sampson, Kevon, Darrah, Erika, Siegel, Richard M., Hasni, Sarfaraz, Andrade, Felipe, Vousden, Katherine A., Mustelin, Tomas, Sims, Gary P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622307/
https://www.ncbi.nlm.nih.gov/pubmed/28993780
http://dx.doi.org/10.3389/fimmu.2017.01200

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