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MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions

CTG•CAG repeat expansions cause at least twelve inherited neurological diseases. Expansions require the presence, not the absence, of the mismatch repair protein MutSβ (Msh2-Msh3 heterodimer). To evaluate properties of MutSβ that drive expansions, previous studies have tested under-expression, ATPas...

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Detalles Bibliográficos
Autores principales:	Keogh, Norma, Chan, Kara Y., Li, Guo-Min, Lahue, Robert S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622409/ https://www.ncbi.nlm.nih.gov/pubmed/28973443 http://dx.doi.org/10.1093/nar/gkx650

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