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Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf: a case report

BACKGROUND: Laterality disorders of the abdominal organs include situs inversus totalis that mirrors the arrangements of all internal organs and heterotaxy syndrome (situs ambiguus) in which the thoracic or abdominal organs are abnormally arranged. Heterotaxy is often accompanied by multiple congeni...

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Autores principales: Kondoh, Daisuke, Kawano, Tomomi, Kikuchi, Tomoaki, Hatate, Kaoru, Watanabe, Kenichi, Sasaki, Motoki, Yamagishi, Norio, Inokuma, Hisashi, Kitamura, Nobuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622422/
https://www.ncbi.nlm.nih.gov/pubmed/28962659
http://dx.doi.org/10.1186/s12917-017-1213-2
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author Kondoh, Daisuke
Kawano, Tomomi
Kikuchi, Tomoaki
Hatate, Kaoru
Watanabe, Kenichi
Sasaki, Motoki
Yamagishi, Norio
Inokuma, Hisashi
Kitamura, Nobuo
author_facet Kondoh, Daisuke
Kawano, Tomomi
Kikuchi, Tomoaki
Hatate, Kaoru
Watanabe, Kenichi
Sasaki, Motoki
Yamagishi, Norio
Inokuma, Hisashi
Kitamura, Nobuo
author_sort Kondoh, Daisuke
collection PubMed
description BACKGROUND: Laterality disorders of the abdominal organs include situs inversus totalis that mirrors the arrangements of all internal organs and heterotaxy syndrome (situs ambiguus) in which the thoracic or abdominal organs are abnormally arranged. Heterotaxy is often accompanied by multiple congenital malformations, and it generally comprises asplenia and polysplenia syndromes. To our knowledge, polysplenia syndrome has been reported in only three cattle, and computerized tomographic (CT) images of these animals were not obtained. CASE PRESENTATION: A six-month-old Holstein heifer had ruminal tympani and right abdominal distension. CT imaging showed that the rumen occupied the right side of the abdominal cavity, the omasum and abomasum occupied the left ventral side and the liver was positioned on the left. The colon and cecum were located at the left dorsum of the cavity, and the left kidney was located more cranially than the right. Postmortem findings revealed two spleens attached to the rumen. Significantly, the duodenum was too short to be divided into segments, except the cranial and descending parts, or flexures, except the cranial flexure, and the pancreas, which lacked a left lobe, was covered with mesojejunum. The liver comprised a relatively large right lobe and a small left lobe without quadrate and caudate lobes. The caudal vena cava that connected to the left azygous vein passed irregularly through the aortic hiatus of the diaphragm, and the common hepatic vein without the caudal vena cava passed through the caval foramen. Although the lungs and heart were morphologically normal, the right atrium received three major systemic veins. Polysplenia syndrome was diagnosed based on the CT and postmortem findings. CONCLUSION: We defined the positions of the abdominal organs and morphological abnormalities in various organs of a calf with polysplenia syndrome based on CT and postmortem findings. These findings will improve understanding of the malpositioning and malformations that can occur in the organs of cattle with polysplenia syndrome. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-017-1213-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-56224222017-10-11 Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf: a case report Kondoh, Daisuke Kawano, Tomomi Kikuchi, Tomoaki Hatate, Kaoru Watanabe, Kenichi Sasaki, Motoki Yamagishi, Norio Inokuma, Hisashi Kitamura, Nobuo BMC Vet Res Case Report BACKGROUND: Laterality disorders of the abdominal organs include situs inversus totalis that mirrors the arrangements of all internal organs and heterotaxy syndrome (situs ambiguus) in which the thoracic or abdominal organs are abnormally arranged. Heterotaxy is often accompanied by multiple congenital malformations, and it generally comprises asplenia and polysplenia syndromes. To our knowledge, polysplenia syndrome has been reported in only three cattle, and computerized tomographic (CT) images of these animals were not obtained. CASE PRESENTATION: A six-month-old Holstein heifer had ruminal tympani and right abdominal distension. CT imaging showed that the rumen occupied the right side of the abdominal cavity, the omasum and abomasum occupied the left ventral side and the liver was positioned on the left. The colon and cecum were located at the left dorsum of the cavity, and the left kidney was located more cranially than the right. Postmortem findings revealed two spleens attached to the rumen. Significantly, the duodenum was too short to be divided into segments, except the cranial and descending parts, or flexures, except the cranial flexure, and the pancreas, which lacked a left lobe, was covered with mesojejunum. The liver comprised a relatively large right lobe and a small left lobe without quadrate and caudate lobes. The caudal vena cava that connected to the left azygous vein passed irregularly through the aortic hiatus of the diaphragm, and the common hepatic vein without the caudal vena cava passed through the caval foramen. Although the lungs and heart were morphologically normal, the right atrium received three major systemic veins. Polysplenia syndrome was diagnosed based on the CT and postmortem findings. CONCLUSION: We defined the positions of the abdominal organs and morphological abnormalities in various organs of a calf with polysplenia syndrome based on CT and postmortem findings. These findings will improve understanding of the malpositioning and malformations that can occur in the organs of cattle with polysplenia syndrome. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-017-1213-2) contains supplementary material, which is available to authorized users. BioMed Central 2017-09-29 /pmc/articles/PMC5622422/ /pubmed/28962659 http://dx.doi.org/10.1186/s12917-017-1213-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kondoh, Daisuke
Kawano, Tomomi
Kikuchi, Tomoaki
Hatate, Kaoru
Watanabe, Kenichi
Sasaki, Motoki
Yamagishi, Norio
Inokuma, Hisashi
Kitamura, Nobuo
Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf: a case report
title Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf: a case report
title_full Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf: a case report
title_fullStr Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf: a case report
title_full_unstemmed Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf: a case report
title_short Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf: a case report
title_sort polysplenia syndrome with duodenal and pancreatic dysplasia in a holstein calf: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622422/
https://www.ncbi.nlm.nih.gov/pubmed/28962659
http://dx.doi.org/10.1186/s12917-017-1213-2
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