Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism

BACKGROUND: DYRK1A maps to the Down syndrome critical region at 21q22. Mutations in this kinase-encoding gene have been reported to cause microcephaly associated with either intellectual disability or autism in humans. Intellectual disability accompanied by microcephaly was recapitulated in a murine...

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Detalles Bibliográficos
Autores principales: Kim, Oc-Hee, Cho, Hyun-Ju, Han, Enna, Hong, Ted Inpyo, Ariyasiri, Krishan, Choi, Jung-Hwa, Hwang, Kyu-Seok, Jeong, Yun-Mi, Yang, Se-Yeol, Yu, Kweon, Park, Doo-Sang, Oh, Hyun-Woo, Davis, Erica E., Schwartz, Charles E., Lee, Jeong-Soo, Kim, Hyung-Goo, Kim, Cheol-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622473/
https://www.ncbi.nlm.nih.gov/pubmed/29021890
http://dx.doi.org/10.1186/s13229-017-0168-2

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