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Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning

BACKGROUND: The Connectivity Map (CMAP) database, an important public data source for drug repositioning, archives gene expression profiles from cancer cell lines treated with and without bioactive small molecules. However, there are only one or two technical replicates for each cell line under one...

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Detalles Bibliográficos
Autores principales:	He, Jun, Yan, Haidan, Cai, Hao, Li, Xiangyu, Guan, Qingzhou, Zheng, Weicheng, Chen, Rou, Liu, Huaping, Song, Kai, Guo, Zheng, Wang, Xianlong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622488/ https://www.ncbi.nlm.nih.gov/pubmed/28962576 http://dx.doi.org/10.1186/s12967-017-1302-9

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