miR-524-5p of the primate-specific C19MC miRNA cluster targets TP53IPN1- and EMT-associated genes to regulate cellular reprogramming

BACKGROUND: Introduction of the transcription factors Oct4, Sox2, Klf4, and c-Myc (OSKM) is able to ‘reprogram’ somatic cells to become induced pluripotent stem cells (iPSCs). Several microRNAs (miRNAs) are known to enhance reprogramming efficiency when co-expressed with the OSKM factors. The primat...

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Detalles Bibliográficos
Autores principales: Nguyen, Phan Nguyen Nhi, Choo, Kong Bung, Huang, Chiu-Jung, Sugii, Shigeki, Cheong, Soon Keng, Kamarul, Tunku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622517/
https://www.ncbi.nlm.nih.gov/pubmed/28962647
http://dx.doi.org/10.1186/s13287-017-0666-3

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