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Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major inter...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622555/ https://www.ncbi.nlm.nih.gov/pubmed/28962617 http://dx.doi.org/10.1186/s12933-017-0604-9 |
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author | Karam, Basil S. Chavez-Moreno, Alejandro Koh, Wonjoon Akar, Joseph G. Akar, Fadi G. |
author_facet | Karam, Basil S. Chavez-Moreno, Alejandro Koh, Wonjoon Akar, Joseph G. Akar, Fadi G. |
author_sort | Karam, Basil S. |
collection | PubMed |
description | Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation. |
format | Online Article Text |
id | pubmed-5622555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-56225552017-10-11 Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes Karam, Basil S. Chavez-Moreno, Alejandro Koh, Wonjoon Akar, Joseph G. Akar, Fadi G. Cardiovasc Diabetol Review Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation. BioMed Central 2017-09-29 /pmc/articles/PMC5622555/ /pubmed/28962617 http://dx.doi.org/10.1186/s12933-017-0604-9 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Karam, Basil S. Chavez-Moreno, Alejandro Koh, Wonjoon Akar, Joseph G. Akar, Fadi G. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes |
title | Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes |
title_full | Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes |
title_fullStr | Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes |
title_full_unstemmed | Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes |
title_short | Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes |
title_sort | oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622555/ https://www.ncbi.nlm.nih.gov/pubmed/28962617 http://dx.doi.org/10.1186/s12933-017-0604-9 |
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