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Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major inter...

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Autores principales: Karam, Basil S., Chavez-Moreno, Alejandro, Koh, Wonjoon, Akar, Joseph G., Akar, Fadi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622555/
https://www.ncbi.nlm.nih.gov/pubmed/28962617
http://dx.doi.org/10.1186/s12933-017-0604-9
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author Karam, Basil S.
Chavez-Moreno, Alejandro
Koh, Wonjoon
Akar, Joseph G.
Akar, Fadi G.
author_facet Karam, Basil S.
Chavez-Moreno, Alejandro
Koh, Wonjoon
Akar, Joseph G.
Akar, Fadi G.
author_sort Karam, Basil S.
collection PubMed
description Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation.
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spelling pubmed-56225552017-10-11 Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes Karam, Basil S. Chavez-Moreno, Alejandro Koh, Wonjoon Akar, Joseph G. Akar, Fadi G. Cardiovasc Diabetol Review Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation. BioMed Central 2017-09-29 /pmc/articles/PMC5622555/ /pubmed/28962617 http://dx.doi.org/10.1186/s12933-017-0604-9 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Karam, Basil S.
Chavez-Moreno, Alejandro
Koh, Wonjoon
Akar, Joseph G.
Akar, Fadi G.
Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
title Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
title_full Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
title_fullStr Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
title_full_unstemmed Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
title_short Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
title_sort oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622555/
https://www.ncbi.nlm.nih.gov/pubmed/28962617
http://dx.doi.org/10.1186/s12933-017-0604-9
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