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Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost

We hypothesized that giving the probiotic strain Lactobacillus reuteri (L. reuteri) DSM 17938 to preterm, formula-fed infants would prevent an early traumatic intestinal inflammatory insult modulating intestinal cytokine profile and reducing the onset of feeding intolerance. Newborn were randomly al...

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Autores principales: Indrio, Flavia, Riezzo, Giuseppe, Tafuri, Silvio, Ficarella, Maria, Carlucci, Barbara, Bisceglia, Massimo, Polimeno, Lorenzo, Francavilla, Ruggiero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622725/
https://www.ncbi.nlm.nih.gov/pubmed/28858247
http://dx.doi.org/10.3390/nu9090965
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author Indrio, Flavia
Riezzo, Giuseppe
Tafuri, Silvio
Ficarella, Maria
Carlucci, Barbara
Bisceglia, Massimo
Polimeno, Lorenzo
Francavilla, Ruggiero
author_facet Indrio, Flavia
Riezzo, Giuseppe
Tafuri, Silvio
Ficarella, Maria
Carlucci, Barbara
Bisceglia, Massimo
Polimeno, Lorenzo
Francavilla, Ruggiero
author_sort Indrio, Flavia
collection PubMed
description We hypothesized that giving the probiotic strain Lactobacillus reuteri (L. reuteri) DSM 17938 to preterm, formula-fed infants would prevent an early traumatic intestinal inflammatory insult modulating intestinal cytokine profile and reducing the onset of feeding intolerance. Newborn were randomly allocated during the first 48 h of life to receive either daily probiotic (10(8) colony forming units (CFUs) of L. reuteri DSM 17938) or placebo for one month. All the newborns underwent to gastric ultrasound for the measurement of gastric emptying time. Fecal samples were collected for the evaluation of fecal cytokines. Clinical data on feeding intolerance and weight gain were collected. The costs of hospital stays were calculated. The results showed that the newborns receiving L. reuteri DSM 17938 had a significant decrease in the number of days needed to reach full enteral feeding (p < 0.01), days of hospital stay (p < 0.01), and days of antibiotic treatment (p < 0.01). Statistically significant differences were observed in pattern of fecal cytokine profiles. The anti-inflammatory cytokine interleukin (IL)-10, was increased in newborns receiving L. reuteri DSM 17938. Pro-inflammatory cytokines: IL-17, IL-8, and tumor necrosis factor (TNF)-alpha levels were increased in newborns given placebo. Differences in the gastric emptying and fasting antral area (FAA) were also observed. Our study demonstrates an effective role for L. reuteri DSM 17938 supplementation in preventing feeding intolerance and improving gut motor and immune function development in bottle-fed stable preterm newborns. Another benefit from the use of probiotics is the reducing cost for the Health Care service.
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spelling pubmed-56227252017-10-05 Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost Indrio, Flavia Riezzo, Giuseppe Tafuri, Silvio Ficarella, Maria Carlucci, Barbara Bisceglia, Massimo Polimeno, Lorenzo Francavilla, Ruggiero Nutrients Article We hypothesized that giving the probiotic strain Lactobacillus reuteri (L. reuteri) DSM 17938 to preterm, formula-fed infants would prevent an early traumatic intestinal inflammatory insult modulating intestinal cytokine profile and reducing the onset of feeding intolerance. Newborn were randomly allocated during the first 48 h of life to receive either daily probiotic (10(8) colony forming units (CFUs) of L. reuteri DSM 17938) or placebo for one month. All the newborns underwent to gastric ultrasound for the measurement of gastric emptying time. Fecal samples were collected for the evaluation of fecal cytokines. Clinical data on feeding intolerance and weight gain were collected. The costs of hospital stays were calculated. The results showed that the newborns receiving L. reuteri DSM 17938 had a significant decrease in the number of days needed to reach full enteral feeding (p < 0.01), days of hospital stay (p < 0.01), and days of antibiotic treatment (p < 0.01). Statistically significant differences were observed in pattern of fecal cytokine profiles. The anti-inflammatory cytokine interleukin (IL)-10, was increased in newborns receiving L. reuteri DSM 17938. Pro-inflammatory cytokines: IL-17, IL-8, and tumor necrosis factor (TNF)-alpha levels were increased in newborns given placebo. Differences in the gastric emptying and fasting antral area (FAA) were also observed. Our study demonstrates an effective role for L. reuteri DSM 17938 supplementation in preventing feeding intolerance and improving gut motor and immune function development in bottle-fed stable preterm newborns. Another benefit from the use of probiotics is the reducing cost for the Health Care service. MDPI 2017-08-31 /pmc/articles/PMC5622725/ /pubmed/28858247 http://dx.doi.org/10.3390/nu9090965 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Indrio, Flavia
Riezzo, Giuseppe
Tafuri, Silvio
Ficarella, Maria
Carlucci, Barbara
Bisceglia, Massimo
Polimeno, Lorenzo
Francavilla, Ruggiero
Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost
title Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost
title_full Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost
title_fullStr Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost
title_full_unstemmed Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost
title_short Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost
title_sort probiotic supplementation in preterm: feeding intolerance and hospital cost
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622725/
https://www.ncbi.nlm.nih.gov/pubmed/28858247
http://dx.doi.org/10.3390/nu9090965
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