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Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women

Carnosine is a naturally occurring intramuscular dipeptide that is thought to attenuate fatigue during high-intensity exercise. Carnosine content is influenced by various factors, including gender and diet. Despite research reporting that carnosine content is lower in women compared to men and lower...

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Autores principales: Varanoske, Alyssa N., Hoffman, Jay R., Church, David D., Wang, Ran, Baker, Kayla M., Dodd, Sarah J., Coker, Nicholas A., Oliveira, Leonardo P., Dawson, Virgil L., Fukuda, David H., Stout, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622748/
https://www.ncbi.nlm.nih.gov/pubmed/28880219
http://dx.doi.org/10.3390/nu9090988
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author Varanoske, Alyssa N.
Hoffman, Jay R.
Church, David D.
Wang, Ran
Baker, Kayla M.
Dodd, Sarah J.
Coker, Nicholas A.
Oliveira, Leonardo P.
Dawson, Virgil L.
Fukuda, David H.
Stout, Jeffrey R.
author_facet Varanoske, Alyssa N.
Hoffman, Jay R.
Church, David D.
Wang, Ran
Baker, Kayla M.
Dodd, Sarah J.
Coker, Nicholas A.
Oliveira, Leonardo P.
Dawson, Virgil L.
Fukuda, David H.
Stout, Jeffrey R.
author_sort Varanoske, Alyssa N.
collection PubMed
description Carnosine is a naturally occurring intramuscular dipeptide that is thought to attenuate fatigue during high-intensity exercise. Carnosine content is influenced by various factors, including gender and diet. Despite research reporting that carnosine content is lower in women compared to men and lower in vegetarians compared to omnivores, no investigations have examined carnosine content in women based on dietary protein intake and its effect on muscle fatigue. Twenty recreationally active women were assigned to either a high (HI; n = 5), moderate (MOD; n = 10), or low (LO; n = 5) group based upon intramuscular carnosine content of the vastus lateralis. Each participant underwent two unilateral maximal voluntary isometric contractions (MVIC) of the knee extensors separated by an isokinetic exercise protocol consisting of five sets of 50 repeated maximal unilateral contractions. Magnitude-based inferences were used to analyze group differences. Percent decline in rate of force development and peak torque (PT) during the MVICs and changes in PT and mean torque during the muscle-fatiguing protocol were lower in HI compared to both MOD and LO. Additionally, absolute and relative dietary protein intake were greater in HI compared to MOD or LO. Results indicated that greater intramuscular carnosine content was reflective of greater dietary protein intake and that individuals with higher carnosine content displayed a greater attenuation of fatigue compared to those with lower carnosine.
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spelling pubmed-56227482017-10-05 Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women Varanoske, Alyssa N. Hoffman, Jay R. Church, David D. Wang, Ran Baker, Kayla M. Dodd, Sarah J. Coker, Nicholas A. Oliveira, Leonardo P. Dawson, Virgil L. Fukuda, David H. Stout, Jeffrey R. Nutrients Article Carnosine is a naturally occurring intramuscular dipeptide that is thought to attenuate fatigue during high-intensity exercise. Carnosine content is influenced by various factors, including gender and diet. Despite research reporting that carnosine content is lower in women compared to men and lower in vegetarians compared to omnivores, no investigations have examined carnosine content in women based on dietary protein intake and its effect on muscle fatigue. Twenty recreationally active women were assigned to either a high (HI; n = 5), moderate (MOD; n = 10), or low (LO; n = 5) group based upon intramuscular carnosine content of the vastus lateralis. Each participant underwent two unilateral maximal voluntary isometric contractions (MVIC) of the knee extensors separated by an isokinetic exercise protocol consisting of five sets of 50 repeated maximal unilateral contractions. Magnitude-based inferences were used to analyze group differences. Percent decline in rate of force development and peak torque (PT) during the MVICs and changes in PT and mean torque during the muscle-fatiguing protocol were lower in HI compared to both MOD and LO. Additionally, absolute and relative dietary protein intake were greater in HI compared to MOD or LO. Results indicated that greater intramuscular carnosine content was reflective of greater dietary protein intake and that individuals with higher carnosine content displayed a greater attenuation of fatigue compared to those with lower carnosine. MDPI 2017-09-07 /pmc/articles/PMC5622748/ /pubmed/28880219 http://dx.doi.org/10.3390/nu9090988 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Varanoske, Alyssa N.
Hoffman, Jay R.
Church, David D.
Wang, Ran
Baker, Kayla M.
Dodd, Sarah J.
Coker, Nicholas A.
Oliveira, Leonardo P.
Dawson, Virgil L.
Fukuda, David H.
Stout, Jeffrey R.
Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women
title Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women
title_full Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women
title_fullStr Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women
title_full_unstemmed Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women
title_short Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women
title_sort influence of skeletal muscle carnosine content on fatigue during repeated resistance exercise in recreationally active women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622748/
https://www.ncbi.nlm.nih.gov/pubmed/28880219
http://dx.doi.org/10.3390/nu9090988
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