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A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren

This study evaluated the effects of a multi-micronutrient fortified juice drink given in different frequencies of consumption on hemoglobin (Hb) concentration of schoolchildren. Hb was measured in 2423 schoolchildren aged 6- to 9-years-old at baseline. All anemic children (n = 246) were randomly all...

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Autores principales: Angeles-Agdeppa, Imelda, Magsadia, Clarita R., Aaron, Grant J., Lloyd, Beate B., Hilmers, David C., Bhutta, Zulfiqar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622762/
https://www.ncbi.nlm.nih.gov/pubmed/28895887
http://dx.doi.org/10.3390/nu9091002
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author Angeles-Agdeppa, Imelda
Magsadia, Clarita R.
Aaron, Grant J.
Lloyd, Beate B.
Hilmers, David C.
Bhutta, Zulfiqar A.
author_facet Angeles-Agdeppa, Imelda
Magsadia, Clarita R.
Aaron, Grant J.
Lloyd, Beate B.
Hilmers, David C.
Bhutta, Zulfiqar A.
author_sort Angeles-Agdeppa, Imelda
collection PubMed
description This study evaluated the effects of a multi-micronutrient fortified juice drink given in different frequencies of consumption on hemoglobin (Hb) concentration of schoolchildren. Hb was measured in 2423 schoolchildren aged 6- to 9-years-old at baseline. All anemic children (n = 246) were randomly allocated into groups: Daily dose (HD: high dose), 5X/week (MD: Moderate Dose), 3X/week (LD: Low Dose) and unfortified (Control). Pre- and post-study measurements of micronutrients were collected from 228 children. At the endpoint, significant Hb increases were observed in all groups, but there was no significant difference between groups. There was a significant reduction in anemia prevalence in all groups from 100% to 36% (Control), 30% (LD), 23% (MD) and 26% (HD). No dose-response effect was observed in Hb in this population. Most likely, this resulted from better than expected micronutrient status and lower than expected severity of anemia and micronutrient deficiencies in this cohort. It is unlikely that the addition of a fortified beverage to school feeding programs in this population would have a positive impact. Whether such an intervention would be cost-effective as a preventative approach needs to be assessed. This study demonstrates the importance of targeting such interventions to appropriate populations.
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spelling pubmed-56227622017-10-05 A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren Angeles-Agdeppa, Imelda Magsadia, Clarita R. Aaron, Grant J. Lloyd, Beate B. Hilmers, David C. Bhutta, Zulfiqar A. Nutrients Article This study evaluated the effects of a multi-micronutrient fortified juice drink given in different frequencies of consumption on hemoglobin (Hb) concentration of schoolchildren. Hb was measured in 2423 schoolchildren aged 6- to 9-years-old at baseline. All anemic children (n = 246) were randomly allocated into groups: Daily dose (HD: high dose), 5X/week (MD: Moderate Dose), 3X/week (LD: Low Dose) and unfortified (Control). Pre- and post-study measurements of micronutrients were collected from 228 children. At the endpoint, significant Hb increases were observed in all groups, but there was no significant difference between groups. There was a significant reduction in anemia prevalence in all groups from 100% to 36% (Control), 30% (LD), 23% (MD) and 26% (HD). No dose-response effect was observed in Hb in this population. Most likely, this resulted from better than expected micronutrient status and lower than expected severity of anemia and micronutrient deficiencies in this cohort. It is unlikely that the addition of a fortified beverage to school feeding programs in this population would have a positive impact. Whether such an intervention would be cost-effective as a preventative approach needs to be assessed. This study demonstrates the importance of targeting such interventions to appropriate populations. MDPI 2017-09-12 /pmc/articles/PMC5622762/ /pubmed/28895887 http://dx.doi.org/10.3390/nu9091002 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Angeles-Agdeppa, Imelda
Magsadia, Clarita R.
Aaron, Grant J.
Lloyd, Beate B.
Hilmers, David C.
Bhutta, Zulfiqar A.
A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren
title A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren
title_full A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren
title_fullStr A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren
title_full_unstemmed A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren
title_short A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren
title_sort micronutrient fortified beverage given at different dosing frequencies had limited impact on anemia and micronutrient status in filipino schoolchildren
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622762/
https://www.ncbi.nlm.nih.gov/pubmed/28895887
http://dx.doi.org/10.3390/nu9091002
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