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Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk
Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 old...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622796/ https://www.ncbi.nlm.nih.gov/pubmed/28930197 http://dx.doi.org/10.3390/nu9091036 |
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author | Bargalló, Núria Gilabert, Rosa Romero-Mamani, Edwin-Saúl Cofán, Montserrat Calder, Philip C. Fitó, Montserrat Corella, Dolores Salas-Salvadó, Jordi Ruiz-Canela, Miguel Estruch, Ramon Ros, Emilio Sala-Vila, Aleix |
author_facet | Bargalló, Núria Gilabert, Rosa Romero-Mamani, Edwin-Saúl Cofán, Montserrat Calder, Philip C. Fitó, Montserrat Corella, Dolores Salas-Salvadó, Jordi Ruiz-Canela, Miguel Estruch, Ramon Ros, Emilio Sala-Vila, Aleix |
author_sort | Bargalló, Núria |
collection | PubMed |
description | Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques. |
format | Online Article Text |
id | pubmed-5622796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56227962017-10-05 Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk Bargalló, Núria Gilabert, Rosa Romero-Mamani, Edwin-Saúl Cofán, Montserrat Calder, Philip C. Fitó, Montserrat Corella, Dolores Salas-Salvadó, Jordi Ruiz-Canela, Miguel Estruch, Ramon Ros, Emilio Sala-Vila, Aleix Nutrients Article Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques. MDPI 2017-09-20 /pmc/articles/PMC5622796/ /pubmed/28930197 http://dx.doi.org/10.3390/nu9091036 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bargalló, Núria Gilabert, Rosa Romero-Mamani, Edwin-Saúl Cofán, Montserrat Calder, Philip C. Fitó, Montserrat Corella, Dolores Salas-Salvadó, Jordi Ruiz-Canela, Miguel Estruch, Ramon Ros, Emilio Sala-Vila, Aleix Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk |
title | Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk |
title_full | Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk |
title_fullStr | Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk |
title_full_unstemmed | Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk |
title_short | Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk |
title_sort | red blood cell eicosapentaenoic acid inversely relates to mri-assessed carotid plaque lipid core burden in elders at high cardiovascular risk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622796/ https://www.ncbi.nlm.nih.gov/pubmed/28930197 http://dx.doi.org/10.3390/nu9091036 |
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