Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute lymphoblastic leukemia

Genetic alterations of the transcription factor IKZF1 (“IKAROS”) are detected in around 15–30% of cases of BCR-ABL-negative B-cell precursor acute lymphoblastic leukemia. Different types of intragenic deletions have been observed, resulting in a functionally inactivated allele (“loss-of-function”) o...

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Detalles Bibliográficos
Autores principales: Kobitzsch, Benjamin, Gökbuget, Nicola, Schwartz, Stefan, Reinhardt, Richard, Brüggemann, Monika, Viardot, Andreas, Wäsch, Ralph, Starck, Michael, Thiel, Eckhard, Hoelzer, Dieter, Burmeister, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622858/
https://www.ncbi.nlm.nih.gov/pubmed/28751559
http://dx.doi.org/10.3324/haematol.2016.161273

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