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FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state

OBJECTIVE: (18)F-fluoromisonidazole (FMISO), a well-known PET imaging probe for diagnosis of hypoxia, is believed to accumulate in hypoxic cells via covalent binding with macromolecules after reduction of the nitro group. Previously, we showed the majority of (18)F-FMISO was incorporated into low-mo...

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Detalles Bibliográficos
Autores principales:	Masaki, Yukiko, Shimizu, Yoichi, Yoshioka, Takeshi, Nishijima, Ken-ichi, Zhao, Songji, Higashino, Kenichi, Numata, Yoshito, Tamaki, Nagara, Kuge, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Japan 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622914/ https://www.ncbi.nlm.nih.gov/pubmed/28695498 http://dx.doi.org/10.1007/s12149-017-1189-9

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