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Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target

Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. Through its C-terminal SH2 domain, Grb7 binds to phosphorylated tyrosine kinases to promote proliferative and migratory signaling. Here, we investigate...

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Detalles Bibliográficos
Autores principales:	Watson, Gabrielle M., Lucas, William A. H., Gunzburg, Menachem J., Wilce, Jacqueline A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623053/ https://www.ncbi.nlm.nih.gov/pubmed/29018805 http://dx.doi.org/10.3389/fmolb.2017.00064

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