A novel antibody against cancer-stem-cell biomarker, DCLK1-S, is potentially useful for assessing colon cancer risk after screening colonoscopy

DCLK1 expression is critically required for maintaining growth of human colon cancer cells (hCCCs). Human colorectal tumors (CRCs) and hCCCs express a novel short isoform of DCLK1 (DCLK1-S) (isoform2) from β-promoter of hDCLK1-gene, while normal-colons express long-isoform (DCLK1-L) (isoform1) from...

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Detalles Bibliográficos
Autores principales: Sarkar, Shubhashish, Popov, Vsevolod L., O’Connell, Malany, Stevenson, Heather L., Lee, Brian S., Obeid, Robert A, Luthra, Gurinder, Singh, Pomila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623180/
https://www.ncbi.nlm.nih.gov/pubmed/28414327
http://dx.doi.org/10.1038/labinvest.2017.40

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