Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and structure-based chemogenomic approach...

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Detalles Bibliográficos
Autores principales: Mugumbate, Grace, Mendes, Vitor, Blaszczyk, Michal, Sabbah, Mohamad, Papadatos, George, Lelievre, Joel, Ballell, Lluis, Barros, David, Abell, Chris, Blundell, Tom L., Overington, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623190/
https://www.ncbi.nlm.nih.gov/pubmed/29018348
http://dx.doi.org/10.3389/fphar.2017.00681

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