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Perforated appendicitis in patients with schizophrenia: a retrospective cohort study
OBJECTIVE: Altered pain sensitivity may affect the outcome of appendicitis in patients with schizophrenia. We aimed to compare the prevalence of perforation in appendicitis between patients with and without schizophrenia. DESIGN: Retrospective cohort study with random matching. SETTING: A single ter...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623499/ https://www.ncbi.nlm.nih.gov/pubmed/28951411 http://dx.doi.org/10.1136/bmjopen-2017-017150 |
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author | Nishihira, Yoshimasa McGill, Rita L Kinjo, Mitsuyo |
author_facet | Nishihira, Yoshimasa McGill, Rita L Kinjo, Mitsuyo |
author_sort | Nishihira, Yoshimasa |
collection | PubMed |
description | OBJECTIVE: Altered pain sensitivity may affect the outcome of appendicitis in patients with schizophrenia. We aimed to compare the prevalence of perforation in appendicitis between patients with and without schizophrenia. DESIGN: Retrospective cohort study with random matching. SETTING: A single tertiary medical centre in Japan. PARTICIPANTS: From 1985 to 2013, 1821 cases of appendicitis requiring appendectomy were collected. Patients with schizophrenia and a cohort of randomly selected control subjects without schizophrenia who underwent appendectomy were identified. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the rate of perforated appendicitis in patients with and without schizophrenia. Secondary outcome was the odds of perforated appendicitis by different clinical factors. RESULTS: 62 patients with schizophrenia and randomly sampled 200 non-schizophrenic patients were compared. The prevalence of perforation was 53% in patients with schizophrenia versus 17% in controls (p<0.0001). The adjusted OR for perforation were 4.87 (95% CI: 2.33 to 10.2) for schizophrenia, 3.35 (95% CI 1.51 to 7.45) for age >55 years and 2.18 (95% CI: 1.12 to 4.27) for delayed presentation. CONCLUSION: Appendiceal perforation was more frequent in patients with schizophrenia than controls, which may be partly attributable to delayed presentation and altered responses to pain. |
format | Online Article Text |
id | pubmed-5623499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-56234992017-10-10 Perforated appendicitis in patients with schizophrenia: a retrospective cohort study Nishihira, Yoshimasa McGill, Rita L Kinjo, Mitsuyo BMJ Open Emergency Medicine OBJECTIVE: Altered pain sensitivity may affect the outcome of appendicitis in patients with schizophrenia. We aimed to compare the prevalence of perforation in appendicitis between patients with and without schizophrenia. DESIGN: Retrospective cohort study with random matching. SETTING: A single tertiary medical centre in Japan. PARTICIPANTS: From 1985 to 2013, 1821 cases of appendicitis requiring appendectomy were collected. Patients with schizophrenia and a cohort of randomly selected control subjects without schizophrenia who underwent appendectomy were identified. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the rate of perforated appendicitis in patients with and without schizophrenia. Secondary outcome was the odds of perforated appendicitis by different clinical factors. RESULTS: 62 patients with schizophrenia and randomly sampled 200 non-schizophrenic patients were compared. The prevalence of perforation was 53% in patients with schizophrenia versus 17% in controls (p<0.0001). The adjusted OR for perforation were 4.87 (95% CI: 2.33 to 10.2) for schizophrenia, 3.35 (95% CI 1.51 to 7.45) for age >55 years and 2.18 (95% CI: 1.12 to 4.27) for delayed presentation. CONCLUSION: Appendiceal perforation was more frequent in patients with schizophrenia than controls, which may be partly attributable to delayed presentation and altered responses to pain. BMJ Publishing Group 2017-09-25 /pmc/articles/PMC5623499/ /pubmed/28951411 http://dx.doi.org/10.1136/bmjopen-2017-017150 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Emergency Medicine Nishihira, Yoshimasa McGill, Rita L Kinjo, Mitsuyo Perforated appendicitis in patients with schizophrenia: a retrospective cohort study |
title | Perforated appendicitis in patients with schizophrenia: a retrospective cohort study |
title_full | Perforated appendicitis in patients with schizophrenia: a retrospective cohort study |
title_fullStr | Perforated appendicitis in patients with schizophrenia: a retrospective cohort study |
title_full_unstemmed | Perforated appendicitis in patients with schizophrenia: a retrospective cohort study |
title_short | Perforated appendicitis in patients with schizophrenia: a retrospective cohort study |
title_sort | perforated appendicitis in patients with schizophrenia: a retrospective cohort study |
topic | Emergency Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623499/ https://www.ncbi.nlm.nih.gov/pubmed/28951411 http://dx.doi.org/10.1136/bmjopen-2017-017150 |
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