Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor

Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 and represses gene expression to regulate cell proliferation and differentiation. Enhancer of zeste homolog 2 (EZH2) or its close homolog EZH1 functions as a catalytic subunit of PRC2, so there are two PRC2 complexes containing eit...

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Detalles Bibliográficos
Autores principales: Honma, Daisuke, Kanno, Osamu, Watanabe, Jun, Kinoshita, Junzo, Hirasawa, Makoto, Nosaka, Emi, Shiroishi, Machiko, Takizawa, Takeshi, Yasumatsu, Isao, Horiuchi, Takao, Nakao, Akira, Suzuki, Keisuke, Yamasaki, Tomonori, Nakajima, Katsuyoshi, Hayakawa, Miho, Yamazaki, Takanori, Yadav, Ajay Singh, Adachi, Nobuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623739/
https://www.ncbi.nlm.nih.gov/pubmed/28741798
http://dx.doi.org/10.1111/cas.13326

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