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Does HbA1c Level Have Clinical Implications in Diabetic Patients Undergoing Coronary Artery Bypass Grafting? A Systematic Review and Meta-Analysis

AIMS/INTRODUCTION: The aim of the present study was to investigate whether HbA1c was related to clinical outcomes in diabetic patients undergoing CABG surgery. MATERIALS AND METHODS: A literature search was carried out satisfying the predefined inclusion criteria from Pubmed, Embase, and Cochrane Li...

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Detalles Bibliográficos
Autores principales: Zheng, Jia, Cheng, Jing, Wang, Tong, Zhang, Qian, Xiao, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623764/
https://www.ncbi.nlm.nih.gov/pubmed/29075292
http://dx.doi.org/10.1155/2017/1537213
Descripción
Sumario:AIMS/INTRODUCTION: The aim of the present study was to investigate whether HbA1c was related to clinical outcomes in diabetic patients undergoing CABG surgery. MATERIALS AND METHODS: A literature search was carried out satisfying the predefined inclusion criteria from Pubmed, Embase, and Cochrane Library. Differences were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) to assess the relationships of preoperative HbA1c levels and clinical prognosis in diabetic patients. RESULTS: 7895 diabetic patients undergoing CABG surgery from eight published studies were finally involved in this meta-analysis. Combined analyses revealed that the higher HbA1c level was significantly associated with increased risks of all-cause mortality (OR 1.56, 95%CI 1.29–1.88), myocardial infarction (OR 2.37, 95%CI 1.21–4.64), and stroke (OR 2.07, 95%CI 1.29–3.32) after CABG surgery. However, there was no significant relationship between HbA1c levels and renal failure (OR 2.08, 95%CI 0.96–4.54) in diabetic patients undergoing CABG surgery. CONCLUSIONS: Our meta-analysis demonstrated that the HbA1c level is potentially associated with increased risks of all-cause mortality, myocardial infarction, and stroke in diabetic subjects undergoing CABG surgery. However, further clinical studies with larger sample sizes and longer follow-up period are urgently warranted.