An improved digital polymerase chain reaction protocol to capture low‐copy KRAS mutations in plasma cell‐free DNA by resolving ‘subsampling’ issues

Genetic alterations responsible for the initiation of cancer may serve as immediate biomarkers for early diagnosis. Plasma levels of cell‐free DNA (cfDNA) in patients with cancer are higher than those in healthy individuals; however, the major technical challenge for the widespread implementation of...

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Detalles Bibliográficos
Autores principales: Ono, Yusuke, Sugitani, Ayumu, Karasaki, Hidenori, Ogata, Munehiko, Nozaki, Reo, Sasajima, Junpei, Yokochi, Tomoki, Asahara, Shingo, Koizumi, Kazuya, Ando, Kiyohiro, Hironaka, Katsunori, Daito, Tsutomu, Mizukami, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623814/
https://www.ncbi.nlm.nih.gov/pubmed/28691390
http://dx.doi.org/10.1002/1878-0261.12110

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