Cargando…

CDK6 protects epithelial ovarian cancer from platinum‐induced death via FOXO3 regulation

Epithelial ovarian cancer (EOC) is an infrequent but highly lethal disease, almost invariably treated with platinum‐based therapies. Improving the response to platinum represents a great challenge, since it could significantly impact on patient survival. Here, we report that silencing or pharmacolog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dall'Acqua, Alessandra, Sonego, Maura, Pellizzari, Ilenia, Pellarin, Ilenia, Canzonieri, Vincenzo, D'Andrea, Sara, Benevol, Sara, Sorio, Roberto, Giorda, Giorgio, Califano, Daniela, Bagnoli, Marina, Militello, Loredana, Mezzanzanica, Delia, Chiappetta, Gennaro, Armenia, Joshua, Belletti, Barbara, Schiappacassi, Monica, Baldassarre, Gustavo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623833/ https://www.ncbi.nlm.nih.gov/pubmed/28778953 http://dx.doi.org/10.15252/emmm.201607012

Ejemplares similares

Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity
por: Pellarin, Ilenia, et al.
Publicado: (2020)

Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells
por: Sonego, Maura, et al.
Publicado: (2017)

Identification and Characterization of a New Platinum-Induced TP53 Mutation in MDAH Ovarian Cancer Cells
por: Lorenzon, Ilaria, et al.
Publicado: (2019)

Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo
por: Berton, Stefania, et al.
Publicado: (2014)

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer
por: Sonego, Maura, et al.
Publicado: (2014)

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer
por: Sonego, Maura, et al.
Publicado: (2013)

p27(kip1) expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms
por: Pellizzari, Ilenia, et al.
Publicado: (2016)

Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells
por: Ranzuglia, Valentina, et al.
Publicado: (2020)

Loss of p27(kip1) increases genomic instability and induces radio-resistance in luminal breast cancer cells
por: Berton, Stefania, et al.
Publicado: (2017)

USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability
por: Sonego, Maura, et al.
Publicado: (2019)

CDK4/6 Inhibitors in Combination Therapies: Better in Company Than Alone: A Mini Review
por: Rampioni Vinciguerra, Gian Luca, et al.
Publicado: (2022)

Loss of CDKN1B induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation
por: Segatto, Ilenia, et al.
Publicado: (2023)

CDKN1B mutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer
por: Viotto, Davide, et al.
Publicado: (2020)

Stathmin Is Dispensable for Tumor Onset in Mice
por: D’Andrea, Sara, et al.
Publicado: (2012)

Inhibition of CDK4/6 as Therapeutic Approach for Ovarian Cancer Patients: Current Evidences and Future Perspectives
por: Dall’Acqua, Alessandra, et al.
Publicado: (2021)

p70S6 kinase mediates breast cancer cell survival in response to surgical wound fluid stimulation
por: Segatto, Ilenia, et al.
Publicado: (2014)

HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel
por: Sgubin, Michela, et al.
Publicado: (2022)

Time-tuning cancer therapy
por: Baldassarre, Gustavo, et al.
Publicado: (2015)

STAT3 in Breast Cancer Onset and Progression: A Matter of Time and Context
por: Segatto, Ilenia, et al.
Publicado: (2018)

Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner
por: Armenia, Joshua, et al.
Publicado: (2014)

Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling
por: Segatto, Ilenia, et al.
Publicado: (2014)

p27kip1 expression and phosphorylation dictate Palbociclib sensitivity in KRAS-mutated colorectal cancer
por: Rampioni Vinciguerra, Gian Luca, et al.
Publicado: (2021)

Role of T198 Modification in the Regulation of p27(Kip1) Protein Stability and Function
por: Schiappacassi, Monica, et al.
Publicado: (2011)

Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer
por: Segatto, Ilenia, et al.
Publicado: (2016)

Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human Tumors
por: Cusan, Martina, et al.
Publicado: (2018)

p27kip1 at the crossroad between actin and microtubule dynamics
por: Rampioni Vinciguerra, Gian Luca, et al.
Publicado: (2019)

Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC
por: Perrone, Francesco, et al.
Publicado: (2016)

Radiotherapy-induced miR-223 prevents relapse of breast cancer by targeting the EGF pathway
por: Fabris, L, et al.
Publicado: (2016)

Clonal Evolution of TP53 c.375+1G>A Mutation in Pre- and Post- Neo-Adjuvant Chemotherapy (NACT) Tumor Samples in High-Grade Serous Ovarian Cancer (HGSOC)
por: Garziera, Marica, et al.
Publicado: (2019)

Identification of Novel Somatic TP53 Mutations in Patients with High-Grade Serous Ovarian Cancer (HGSOC) Using Next-Generation Sequencing (NGS)
por: Garziera, Marica, et al.
Publicado: (2018)

The many facets of miR‐223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response
por: Favero, Andrea, et al.
Publicado: (2021)

miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC
por: Citron, Francesca, et al.
Publicado: (2021)

A miRNA signature assessing ovarian cancer prognosis
por: Bagnoli, Marina, et al.
Publicado: (2016)

New Challenges in Tumor Mutation Heterogeneity in Advanced Ovarian Cancer by a Targeted Next-Generation Sequencing (NGS) Approach
por: Garziera, Marica, et al.
Publicado: (2019)

Foliar Application of Silicon in Vitis vinifera: Targeted Metabolomics Analysis as a Tool to Investigate the Chemical Variations in Berries of Four Grapevine Cultivars
por: Sut, Stefania, et al.
Publicado: (2022)

A new role for IDH1 in the control of ovarian cancer cells metabolism and senescence
por: Sonego, Maura, et al.
Publicado: (2020)

Exploring the Insecticidal Potential of Boldo (Peumus boldus) Essential Oil: Toxicity to Pests and Vectors and Non-target Impact on the Microcrustacean Daphnia magna
por: Pavela, Roman, et al.
Publicado: (2019)

Identification of Onosma visianii Roots Extract and Purified Shikonin Derivatives as Potential Acaricidal Agents against Tetranychus urticae
por: Sut, Stefania, et al.
Publicado: (2017)

Prognostic role of bowel involvement in optimally cytoreduced advanced ovarian cancer: a retrospective study
por: Giorda, Giorgio, et al.
Publicado: (2014)

Galanin promotes autophagy and alleviates apoptosis in the hypertrophied heart through FoxO1 pathway
por: Martinelli, Ilenia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9m7daerqchan4gh3i5e7g9p7a5