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Autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment
Background Altered autobiographical memory (ABM) functioning has been implicated in the pathogenesis of depression and post-traumatic stress disorder and may represent one mechanism by which childhood maltreatment elevates psychiatric risk. Aims To investigate the impact of childhood maltreatment on...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal College of Psychiatrists
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623877/ https://www.ncbi.nlm.nih.gov/pubmed/28882830 http://dx.doi.org/10.1192/bjp.bp.117.201798 |
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author | McCrory, Eamon J. Puetz, Vanessa B. Maguire, Eleanor A. Mechelli, Andrea Palmer, Amy Gerin, Mattia I. Kelly, Philip A. Koutoufa, Iakovina Viding, Essi |
author_facet | McCrory, Eamon J. Puetz, Vanessa B. Maguire, Eleanor A. Mechelli, Andrea Palmer, Amy Gerin, Mattia I. Kelly, Philip A. Koutoufa, Iakovina Viding, Essi |
author_sort | McCrory, Eamon J. |
collection | PubMed |
description | Background Altered autobiographical memory (ABM) functioning has been implicated in the pathogenesis of depression and post-traumatic stress disorder and may represent one mechanism by which childhood maltreatment elevates psychiatric risk. Aims To investigate the impact of childhood maltreatment on ABM functioning. Method Thirty-four children with documented maltreatment and 33 matched controls recalled specific ABMs in response to emotionally valenced cue words during functional magnetic resonance imaging. Results Children with maltreatment experience showed reduced hippocampal and increased middle temporal and parahippocampal activation during positive ABM recall compared with peers. During negative ABM recall they exhibited increased amygdala activation, and greater amygdala connectivity with the salience network. Conclusions Childhood maltreatment is associated with altered ABM functioning, specifically reduced activation in areas encoding specification of positive memories, and greater activation of the salience network for negative memories. This pattern may confer latent vulnerability to future depression and post-traumatic stress disorder. |
format | Online Article Text |
id | pubmed-5623877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Royal College of Psychiatrists |
record_format | MEDLINE/PubMed |
spelling | pubmed-56238772017-10-17 Autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment McCrory, Eamon J. Puetz, Vanessa B. Maguire, Eleanor A. Mechelli, Andrea Palmer, Amy Gerin, Mattia I. Kelly, Philip A. Koutoufa, Iakovina Viding, Essi Br J Psychiatry Papers Background Altered autobiographical memory (ABM) functioning has been implicated in the pathogenesis of depression and post-traumatic stress disorder and may represent one mechanism by which childhood maltreatment elevates psychiatric risk. Aims To investigate the impact of childhood maltreatment on ABM functioning. Method Thirty-four children with documented maltreatment and 33 matched controls recalled specific ABMs in response to emotionally valenced cue words during functional magnetic resonance imaging. Results Children with maltreatment experience showed reduced hippocampal and increased middle temporal and parahippocampal activation during positive ABM recall compared with peers. During negative ABM recall they exhibited increased amygdala activation, and greater amygdala connectivity with the salience network. Conclusions Childhood maltreatment is associated with altered ABM functioning, specifically reduced activation in areas encoding specification of positive memories, and greater activation of the salience network for negative memories. This pattern may confer latent vulnerability to future depression and post-traumatic stress disorder. Royal College of Psychiatrists 2017-10 /pmc/articles/PMC5623877/ /pubmed/28882830 http://dx.doi.org/10.1192/bjp.bp.117.201798 Text en © The Royal College of Psychiatrists 2017. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence. |
spellingShingle | Papers McCrory, Eamon J. Puetz, Vanessa B. Maguire, Eleanor A. Mechelli, Andrea Palmer, Amy Gerin, Mattia I. Kelly, Philip A. Koutoufa, Iakovina Viding, Essi Autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment |
title | Autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment |
title_full | Autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment |
title_fullStr | Autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment |
title_full_unstemmed | Autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment |
title_short | Autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment |
title_sort | autobiographical memory: a candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment |
topic | Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623877/ https://www.ncbi.nlm.nih.gov/pubmed/28882830 http://dx.doi.org/10.1192/bjp.bp.117.201798 |
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