Cargando…

BRCA1 regulation on β-hCG: a mechanism for tumorigenicity in BRCA1 defective breast cancer

Human chorionic gonadotropin β (β-hCG) has been implicated in breast tumorigenesis. However, the role of this hormone is highly controversial as certain studies suggest it has anti-tumor properties while others have found it to be pro-tumorigenic. To unveil the truth, we have analyzed the expression...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sengodan, S K, Nadhan, R, Nair, R S, Hemalatha, S K, Somasundaram, V, Sushama, R R, Rajan, A, Latha, N R, Varghese, G R, Thankappan, R k, Kumar, J M, Chil, A, Anilkumar, T V, Srinivas, P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623901/ https://www.ncbi.nlm.nih.gov/pubmed/28869585 http://dx.doi.org/10.1038/oncsis.2017.75

Ejemplares similares

Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB)
por: Nair, Rakesh Sathish, et al.
Publicado: (2016)

Brcal Defective Breast Cancer Cells Induce in vitro Transformation of Cancer Associated Fibroblasts (CAFs) to Metastasis Associated Fibroblasts (MAF)
por: Hemalatha, Sreelatha K., et al.
Publicado: (2018)

Biological functions of hCG and hCG-related molecules
por: Cole, Laurence A
Publicado: (2010)

Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells
por: Somasundaram, Veena, et al.
Publicado: (2016)

Beta-hCG expression by bladder cancers.
por: Iles, R.
Publicado: (1992)

A model of the BRCA1/BRCA2 network
por: Pujana, MA, et al.
Publicado: (2005)

GnRH agonist in association with hCG versus hCG alone for final oocyte maturation triggering in GnRH antagonist cycles
por: de Oliveira Filho, Condesmar M., et al.
Publicado: (2021)

Validation of (125)I-hCG as a marker for elimination of hCG and stability of (125)I-hCG after in vivo injection in humans
por: Christensen, T B, et al.
Publicado: (1999)

Different hCG assays to measure ectopic hCG secretion in bladder carcinoma patients.
por: Mora, J., et al.
Publicado: (1996)

BRCA1, BRCA2 and their possible function in DNA damage response
por: Kote-Jarai, Z, et al.
Publicado: (1999)

BRCA1 polymorphisms.
por: Campbell, I. G., et al.
Publicado: (1997)

Comparison of hCG triggering versus hCG in combination with a GnRH agonist: a prospective randomized controlled trial
por: Decleer, W., et al.
Publicado: (2014)

hCG, the wonder of today's science
por: Cole, Laurence A
Publicado: (2012)

Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Rebbeck, Timothy R, et al.
Publicado: (2008)

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
por: Maxwell, Kara N., et al.
Publicado: (2017)

Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations
por: Whittemore, A S, et al.
Publicado: (2004)

BRCA1 and BRCA2 Gene Mutations Screening In Sporadic Breast Cancer Patients In Kazakhstan
por: Akilzhanova, Ainur R., et al.
Publicado: (2013)

BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
por: Cline, Melissa S., et al.
Publicado: (2018)

hCG: Biological Functions and Clinical Applications
por: Nwabuobi, Chinedu, et al.
Publicado: (2017)

hCG Triggering in ART: An Evolutionary Concept
por: Hershko Klement, Anat, et al.
Publicado: (2017)

Determinants of the hCG Concentration in the Early Luteal Phase After Final Maturation of Follicles With Bolus Trigger of Recombinant hCG
por: Vuong, Lan N., et al.
Publicado: (2020)

Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2
por: Osorio, A, et al.
Publicado: (2011)

BRCA1 and BRCA2 in breast cancer families from Wales: moderate mutation frequency and two recurrent mutations in BRCA1.
por: Lancaster, J. M., et al.
Publicado: (1998)

BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells
por: Tassone, P, et al.
Publicado: (2003)

Structure-Function of the Tumor Suppressor BRCA1
por: Clark, Serena L., et al.
Publicado: (2012)

Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations
por: Duffy, S W, et al.
Publicado: (2002)

Breast tumor characteristics of BRCA1 and BRCA2 gene mutation carriers on MRI
por: Veltman, J., et al.
Publicado: (2008)

Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome
por: Homer, Michael V, et al.
Publicado: (2019)

BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts
por: Lohse, I, et al.
Publicado: (2015)

A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function
por: Kononenko, Artem V., et al.
Publicado: (2014)

The germline mutational landscape of BRCA1 and BRCA2 in Brazil
por: Palmero, Edenir Inêz, et al.
Publicado: (2018)

Parity and breast cancer risk among BRCA1 and BRCA2 mutation carriers
por: Antoniou, Antonis C, et al.
Publicado: (2006)

Association of serum beta hCG levels in women with palpable malignant breast lesions
por: Mohammed, Ashfaque, et al.
Publicado: (2023)

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
por: Osorio, A, et al.
Publicado: (2009)

Incidence and impact of brain metastasis in patients with hereditary BRCA1 or BRCA2 mutated invasive breast cancer
por: Garber, Haven R., et al.
Publicado: (2022)

Difficulties in cerebrospinal fluid βhCG interpretation in a patient with an infundibular lesion
por: Jones, Alicia R, et al.
Publicado: (2018)

Genome-Wide Gene Expression Analyses of BRCA1- and BRCA2-Associated Breast and Ovarian Tumours
por: Wiggins, George A. R., et al.
Publicado: (2020)

Rapid evolution of BRCA1 and BRCA2 in humans and other primates
por: Lou, Dianne I, et al.
Publicado: (2014)

Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML
por: Hart, Steven N., et al.
Publicado: (2020)

Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty
por: Chen, Han, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_86chj4bce8i8ng8e3gos6bvub3