Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy

Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis. As tumor cells lose the requirement for anchorage to ECM, they rely on cell–cell adhesion ‘multicellular aggregation’ for surviva...

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Detalles Bibliográficos
Autores principales: Woolf, N, Pearson, B E, Bondzie, P A, Meyer, R D, Lavaei, M, Belkina, A C, Chitalia, V, Rahimi, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623903/
https://www.ncbi.nlm.nih.gov/pubmed/28920928
http://dx.doi.org/10.1038/oncsis.2017.77

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