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Unintended target effect of anti-BCL-2 DNAi

INTRODUCTION: Previous research suggested that a novel compound PNT2258 inhibits B-cell lymphoma 2 (BCL-2) transcription by DNA interference (DNAi) and demonstrated its activity in preclinical xenograft models and in a pilot Phase II clinical trial in non-Hodgkin’s lymphoma (NHL). While the drug dow...

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Detalles Bibliográficos
Autores principales:	Ebrahim, Abdul Shukkur, Kandouz, Mustapha, Emara, Nada, Sugalski, Amara B, Lipovich, Leonard, Al-Katib, Ayad M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624602/ https://www.ncbi.nlm.nih.gov/pubmed/28989285 http://dx.doi.org/10.2147/CMAR.S139105

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