Effects of meal composition and meal timing on the expression of genes involved in hepatic drug metabolism in rats

INTRODUCTION: With chronotherapy, drug administration is synchronized with daily rhythms in drug clearance and pharmacokinetics. Daily rhythms in gene expression are centrally mastered by the suprachiasmatic nucleus of the hypothalamus as well as by tissue clocks containing similar molecular mechani...

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Detalles Bibliográficos
Autores principales: de Vries, E. M., Oosterman, J. E., Eggink, H. M., de Goede, P., Sen, S., Foppen, E., Boudzovitch-Surovtseva, O., Boelen, A., Romijn, J. A., laFleur, S. E., Kalsbeek, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624615/
https://www.ncbi.nlm.nih.gov/pubmed/28968417
http://dx.doi.org/10.1371/journal.pone.0185520

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